Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"D-aspartate"”.
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STRATEGIES TO TARGET HUMAN D-ASPARTATE OXIDASE AND MODULATE ENDOGENOUS D-ASPARTATE LEVELS IN SCHIZOPHRENIA
D-aspartate (D-Asp) is abundant in mammal brain at embryonal level while it rapidly decreases at post-natal stages due to the enhanced activity of D-aspartate oxidase (DASPO). D-Asp participates to glutamatergic neurotransmission and alterations of physiological metabolism are linked to …
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Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development
Disruptions in glutamatergic neurotransmission may play a role in the pathogenesis of schizophrenia. The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition …
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Effects of N-Methyl-D-Aspartate receptor blockade on cross-sensitization between D-Tyr11 neurotensin and amphetamine
Blockade of neurotensin (NT) receptors with SR-48692 prevents the development of sensitization to the locomotor activating effects of amphetamine (AMPH). In addition, repeated icv injections of NT or of its analog, D-Tyr 11 NT, sensitize animals to the locomotor activating effects of AMPH. Recent …
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Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors
Clinical use of phencyclidine (PCP), a potent dissociative anesthetic, was abandoned as a result of reports of post-operative hallucinations and disoriented behavior; further, illicit use has substantially diminished because of its psychotomimetic properties. PCP intoxication in humans has also …
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Analysis of D-Aspartate as a Signaling Molecule in the Aplysia Californica Central Nervous System Using Capillary Electrophoresis and Radioisotopic Labeling
… cell-cell signaling molecule investigated is D-aspartate (D-Asp). D-Asp is present in the nervous systems of both vertebrates and invertebrates, and its biosynthesis has been observed in mammalian cells. We suspect that D-Asp acts as a classical neurotransmitter in the central nervous system. …
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Amino acid racemase responsible for the biosynthesis of D-aspartate and D-serine signaling molecules in Aplysia californica central nervous system
… affect the activity and plasticity of N-methyl-D-aspartate (NMDA) receptor, a molecule that forms the basis of learning and memory in the brain. D-aspartate (D-Asp) is found in neuroendocrine and endocrine tissues, potentially playing roles in hormone synthesis and/or release. However, many …
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The Influence of Propofol Administration Time on Oxygen Glucose Deprivation-Reperfusion Injury in Rat mixed Cortical Cultures Focused on N-Methyl-D-Aspartate (NMDA) Receptor
… cascade mainly by overstimulation of N-methyl-D-aspartate (NMDA) receptors. Propofol have been known to have neuroprotective effects. However, the effect of administration time is not well known with in vitro model. This study was conducted to determine whether the propofol administration time …
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Excitotoxicity, oxidative stress and neuroprotection in cerebellar granule neurones
… considered the effects of glutamate, N-methyl-D-aspartate, 3-nitropropionic acid and oxygen-glucose deprivation. Additionally, extensive study was carried out of the actions of increased glucose concentration and a range of metabolites of the essential amino acid tryptophan. It was demonstrated …
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Inhibition of excitatory neurotransmitter activity by hydrogen sulfide in bovine retina, in vitro
… mM)-induced glutamate release (measured as [3H]D-aspartate) in bovine isolated retina using the superfusion method. Furthermore, I investigated the ability of various H2S donor drugs to protect bovine retinal neurons from glutamate-induced toxicity using the MTT assay. |The H2S donor drugs, …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… of EAAT3 preferring inhibitors, L-β-benzyl aspartate (L-β-BA) and L-β-BA derivatives. L-β-BA and derivatives were initially synthesized in an approximate 2:1 ratio of diasteromers (threo:erythro), using base promoted enolate addition. Kinetic analysis of 3H-D-aspartate uptake …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… of EAAT3 preferring inhibitors, L-β-benzyl aspartate (L-β-BA) and L-β-BA derivatives. L-β-BA and derivatives were initially synthesized in an approximate 2:1 ratio of diasteromers (threo:erythro), using base promoted enolate addition. Kinetic analysis of 3H-D-aspartate uptake …
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The synthesis and pharmacology of some novel excitatory amino acid analogues
Certain amino acids, notably L-glutamate and L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… (AT1R), insulin receptors, and N-methyl-D-aspartate receptors (NMDAR) on TRPC6 activity are studied here. In acutely isolated rat glomeruli, angiotensin causes an upregulation of TRPC6 activity, and this is mediated by the Gαq /PLC pathway. This angiotensin-evoked upregulation is partially …
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Regulation of Excitatory Neurotransmission, Synaptic Plasticity, and Learning by Cyclin-Dependent Kinase 5
… enhanced mice displayed increased N-methyl-D-aspartate receptor-mediated currents and elevated levels of the NR2B N-methyl-D-aspartate receptor subunit. The enhancement in synaptic plasticity was directly attributed to the increased current through NR2B-containing receptors. NR2B levels were …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… synapse. Here we show that transport of D-aspartate, a non-metabolized L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ wildtype (WT) mice. Experiments using EAAT …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… synapse. Here we show that transport of D-aspartate, a non-metabolized L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ wildtype (WT) mice. Experiments using EAAT …
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Analysis of endogenous D-amino acids in the central nervous system and endocrine system via capillary electrophoresis with biochemical sample treatment
… effect. These endogenous D-amino acids include D-aspartate, D-alanine, and D-glutamate that are found in a diverse range of animals. A major challenge in endogenous D-amino acid research is to distinguish D-amino acids from abundant L-amino acids. Furthermore, neuronal sample volume is usually …
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