Global ETD Search
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Showing 1 to 6 of 6 for “"D-amino acid-containing peptides"”.
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Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
Other PTMs, such as the transformation of L-amino acid residues to the D-configuration, do not result in a measurable mass change. Capillary electrophoresis combined with mass spectrometry is used to identify cells containing a D-amino acid-containing peptide found in Aplysia. These cells are then …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
… a combinatorial screening approach, six novel D-amino acid containing peptides were identified and analyzed for their ability to adhere to human prostate tumor cells, support tumor cell adhesion and inhibit tumor cell adhesion to ECM proteins. Two peptides, RZ-3 (kmviywkag) and HYD1 (kikmviswkg) …
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Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection
… L-Asp. A method for single cell analysis of D-amino acid containing peptides in Aplysia abdominal neurons has been developed and the D-form dominates in one diastereomer pair. Lastly, in preliminary studies, the release of L-Glu versus acetylcholine from specific regions of the brain of freely …
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Characterization of D-amino acid-containing neuropeptides from metazoa
The predominance of left-handedness in amino acids and proteins in living organisms is well established. The presence of D-amino acids in the prokaryotes (e.g., bacterial cell wall and lantibiotics) has been considered exceptions to this rule. In the animal kingdom, proteins are thought to be more …
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Analysis of enzymatic L/D-peptide isomerization in animals
The study of cell-to-cell signaling peptides contributes to the fundamental understanding of physiological processes and improves the effectiveness of pharmaceutical drugs. While protein synthesis in animals is stereospecific for all L-form amino acids, a unique and bioactive group of D-amino …
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Analysis of D-amino acid-containing neuropeptides in mollusks and rodents
… on the peptide level, with sometimes hundreds of peptides expressed by or secreted onto specific structures. These neuropeptides have evolved for animal behaviors and regulating neuronal circuits. Neuropeptides exert their responses through GPCRs in most cases, and in order to interact with the …