Global ETD Search
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Showing 1 to 3 of 3 for “"D-2-Hydroxyglutarate"”.
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Förster Resonance Energy Transfer-Based Quantification of D-2-Hydroxyglutarate & Locked Nucleic Acid Loop-Mediated Isothermal Amplification Mediated Detection of IDH1-R132 Single Nucleotide Variants in Glioma
… status. The fluorescent biosensor quantifies D-2-Hydroxyglutarate (D-2-HG), an oncometabolite and surrogate marker of <em>IDH1</em> mutations, while the genotyping panel identifies the specific <em>IDH1</em>-R132 single nucleotide variant (SNV) present. The biosensor’s robust function in …
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A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
… catalyze isocitrate to the oncometabolite D-2-hydroxyglutarate (2-HG) instead of alpha-ketoglutarate (α-KG). As 2-HG accumulates, it induces a hypermethylator phenotype that prevents the cells from differentiating. Acquisition of additional mutations in tumor suppressors such as p53 and/or ATRX …
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Energy metabolism in Arbidopsis thaliana: TCA cycle evolution, amino acids degradation and alternative pathways
… isovaleryl- CoA dehydrogenase (IVDH) and (D)-2-hydroxyglutarate dehydrogenase (D2HGDH) have been characterized as electron donnor to the ubiquinol pool via this system so far by the degradation of BCAA and lysine, respectively. In fact, BCAA catabolism is of pivotal importance to provide …