Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Cytoxicity."”.
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Opto-Electronic Modulation of Quantum Dots by Cells and Bioactive Molecules
… research has focused on the biocompatibility and cytoxicity of QDs in the context of imaging/therapy. However, there is a paucity of work on how biological systems and bioactive molecules might be used to alter the opto-electronic properties of QDs.|Here, we show that these properties can be …
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Biomolecular interactions and cellular effects of steroidal and metallosupramolecular metallodrugs
… coupling has negative effects. In Chapter 4 the cytoxicity and cellular behaviour of metallosupramolecular cylinders are studied. It is shown that these complexes can cross the cellular membrane, concentrating in the nuclei where they can interact with cellular DNA.
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In vitro cytotoxic activity of equine lymphocytes on equine herpesvirus-1 infected allogenic fibroblasts
… phenotypically identified cells and the percent cytoxicity, although several negative correlations were present. This suggests that the cytotoxic activity was either not mediated by any of the phenotypically identified cell populations or that the activity was mediated by several different cell …
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Development of a Nanoparticle Vaccine Delivery System with Polymeric Oral Adjuvants for Poultry
… the NP delivery system to minimize immune cell cytoxicity for the vaccine delivery application 3. Fabricate and characterize FPV and HEV viral nanoparticles' stability, cellular uptake/infectivity, and released viruses' ability to replicate 4. Compare the abilities of the killed HEV nanovaccine, …
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The evaluation of targeted radionuclide therapies and radio sensitising agents in malignant melanoma
… growth delay. The MRE11 inhibitor Mirin produced cytoxicity in vitro but not in vivo when combined with 2Gy X-ray radiation, reducing but not inhibiting γH2AX foci clearance post radiation treatment. The novel IKKβ Inhibitors SU567 and SU182 produce effects consistent with IKKβ inhibition and are …
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In vitro cytotoxicity and skin irritation testing of antimicrobial conjugated electrolytes : interactions with mammalian cells
… of CPEs to mammalian cells at three levels: cytoxicity testing of cell monolayers, skin irritation testing of tissues, and intracellular co-localization. Eight CPEs, two PPEs and six OPEs, were selected for these studies based on biocidal activity and diversity of repeat unit number and …
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Pengaruh ekstrak pegagan (Centella asiatica linn.) terhadap pertumbuhan kultur primer sel hepar baby hamster yang dipapar 7.12- dimetilbenz(α)antrasen
… (Centella asiatica Linn.) against the growth and cytoxicity of primary Cell cultures hepar baby hamster being 7.12-Dimethylbenz(α)anthracene. This research uses experimental design with 7 treatments and three times repeats. The treatment used is the new breed of primary culture of cells being the …
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The activity of pH membrane disruptive pseudopeptides and their subcellular fate in mammalian cells cultured in-vitro
… pH. Pseudopepides were investigated for their cytoxicity towards a well known cell line, namely C26 (colorectal adenocarcinoma) and were shown through the use of a cell viability assay, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide) to be well tolerated by C26 cells over a …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… input and cataplerotic block on HG/PA-induced cytoxicity was also observed in primary islet beta cells isolated from Zuker Diabetic Fatty (ZDF) or Otsuka Long-Evans Tokushima Fatty (OLETF) rats. These works suggest that energy depletion, by shortage of Krebs intermediates, may play a critical …
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Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
… of the γδ⁺ T cell effectors, indicating that cytoxicity was mediated predominantly by the granule exocytosis/ perforin pathway. Despite being strongly cytolytic against infected U937 cells, however, the γδ⁺ CTL clones did not have any impact on the survival of intracellular M. tuberculosis. …
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Identifying vaping hazards through the evaluation of exposure methods and cell culture models for e-liquid mixtures.
Vaping has become a popular method of engaging in “smokeless” socialization since the introduction of e-cigarettes in the United States tobacco market. In 2007, e-cigarettes were presented as portable vaping devices serving as alternatives to traditional tobacco cigarettes. Due to the evolution of …