Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Cytotrophoblast"”.
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Expression and effects of epidermal growth factor related peptides in human term gestational tissue
… member of the E G F family, on cultured villous cytotrophoblast (CT) cells isolated from placentae delivered between 38-40 weeks gestation.
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Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
… trophectoderm, postimplantation luminal cytotrophoblast, and postimplantation syncytiotrophoblast. Marmoset trophectoderm differentiated into syncytiotrophoblast upon implantation but did not form invasive extravillous trophoblast. Staining of in utero embryos demonstrated extensive …
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ROLES OF SULFOTRANSFERASE ENZYMES IN TRANS-PLACENTAL DISPOSITION
… SULT1A3, SULT1E1, and SULT2A1) in primary cytotrophoblast cells and the trophoblast-like BeWo cell line. These isoforms have been reported to be functional in human placenta. Our results indicated that the phenolic sulfotransferase isoforms, SULT1A1 and SULT1A3, are functional in BeWo, as …
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Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… produced through fusion of underlying progenitor cytotrophoblast cells with the multinucleated syncytiotrophoblast layer. The MacPhee laboratory has previously established that fusion or syncytialization of cytotrophoblasts is aided by expression of integrin-linked kinase (ILK), a cytoplasmic …
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Ανοσοϊστοχημική μελέτη του πλακούντα με ιδιαίτερη έμφαση στα κύτταρα Hofbauer
… the present study. 5. Positive reaction of the cytotrophoblast was demonstrated for Cytokeratin, CALLA, a1-AcT and a1-AT. There was practically no reaction to the other antigens. 6. We believe the presence of EMA in the trophoblast in the last trimester is probably associated with the maturation …
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Acetyl-CoA metabolism and human trophoblast differentiation
Cytotrophoblasts are trophoblast stem cells that undergo rapid self-renewal and differentiation during early pregnancy. Disruptions in this process can lead to impaired placentation or placental dysfunction leading to complications in pregnancy. This thesis investigates the role of ATP citrate …
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Adaptation to environmental stress in the human placenta
… and increased expression of genes involved in cytotrophoblast fusion including the gene dysferlin (DYSF). Upon closer examination we noticed that DYSF had a variant (rs10166384;G/A) at a methylation site with 3 levels of DNA methylation corresponding to individual genotypes. We tested for …
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Ryanodine receptor expression in trophoblasts
… indicated that both syncytiotrophoblast and cytotrophoblast cell layers were positively stained by antibodies recognising RyRs; likewise, expression of RyR isoforms was also revealed in BeWo and JEG-3 cells by immunofluorescence microscopy. In addition, changes in [Ca2+]i were observed in …
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The expression of Heat Shock Protein 70 in the placental tissue with preeclampsia
… of Hsp70 was observed in syncytiotrophoblast, cytotrophoblast, intravillous endothelial cells, extravillous trophoblast in basal layer and decidual cell. And according to the intensity of immunostaining, we compared these three groups. Western blot analysis was performed and the quantification …
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The Role of MicroRNA-378a-5p and its Target Genes in Differentiation and Fusion of BeWo Cells
… and formed from the fusion of mononucleated cytotrophoblast (CTBs), syncytiotrophoblasts (STBs) are the primary site of numerous placental functions such as exchange of respiratory gases and waste products, transport of nutrients and hormones production. We have previously shown that …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… found to be more similar to nondifferentiated cytotrophoblast with respect to their ABC protein expression profile, whereas BeWo cells more closely reflected differentiated syncytiotrophoblast. Treatment of primary term trophoblasts in vitro with cytokines (TNF- or IL-1) decreased expression …
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Human trophoblast survival and invasion in the developing placenta: autocrine regulation by hbegf
… protein in early pregnancy that induces cytotrophoblast (CTB) cell differentiation to an invasive phenotype, protects against apoptosis, and is involved in an autocrine signaling mechanism that leads to its own protein synthesis. CTBs exist in a low O<sub>2</sub> environment during the …