Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1264 for “"Cytotoxicity"”.
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Microfluidic device for cytotoxicity screening
Cytotoxicity screening is important for the identification of different toxins and the quantification of toxin concentrations that can be detrimental to the proliferation of mammalian cells. Current cytotoxicity screening method requires initial cell seeding in 96-well cell culture plates and a …
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Cellular Mechanism of Arglabin-Dimethylaminohydrochloride Cytotoxicity
<p>Cancer is the second leading killer in the United States. Anticancer drug development is always based on the understanding of molecular and cellular mechanisms of carcinogenesis, as well as comprehensive knowledge of potential anticancer drugs. Arglabin-dimethylaminohydrochloride (arglabin-DMA) …
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Nonspecific Cell-Mediated Cytotoxicity in the Cat
Using a chromium-51-release microcytotoxicity assay, naturally occurring cytotoxic cells were demonstrated in peripheral blood and spleens of domestic cats. Lymphocytes from blood and spleen were purified over Ficoll-Hypaque and added to uninfected, vaccinia-infected, or herpes-infected adherent …
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Mitochondrial regulation of CD8+ T cell cytotoxicity
… motility, signalling, energy requirements and cytotoxicity in CD8+ T cells derived from splenocytes of Usp30-/- mice. Furthermore, I test different mitochondrial functions using both genetic and pharmacological manipulation of oxidative phosphorylation, mitochondrial calcium flux and …
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Studies of hyperphosphorylated tau aggregation and cytotoxicity
Diffusible aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase …
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Synthesis and Cytotoxicity Studies of Gold Nanoparticle Systems
… a series of end-point based in vitro assays. The cytotoxicity, namely the causation of necrotic cell death was studied using the neutral red assay on CHO22 cell line. All three system types showed benign cytotoxicity properties; demonstrating minor dose-dependence decline in cell viability through …
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Controlled delivery of nitric oxide for cytotoxicity studies
Endogenous synthesis of nitric oxide (NO) is essential for many physiological functions, including the immune defense. However, the sustained, high production of NO by immune cells (macrophages) that accompanies chronic inflammation may be cytotoxic, mutagenic and carcinogenic. To better understand …
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The Molecular Mechanisms of Organophosphorus Compound-induced Cytotoxicity
… time, and the presence of modulators of cytotoxicity such as phenylmethylsulfonyl fluoride (PMSF), carbachol, Ac-DEVD-CHO, Ac-IETD-CHO, and cyclosporin A. Preliminary in vivo experiments designed to validate in vitro results revealed neural degeneration involving fibers, terminals, and …
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Synthesis of Cadmium Selenide Quantum Dots and Their Cytotoxicity
Cadmium selenide (CdSe) nanoparticles (NPs) have applications in biomedical, biochemistry, bioimaging areas through different methods such as cell labelling and drug delivery (Chapter1). This study aims to test the optical and biological properties of CdSe NPs so that its applications can be …
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Cytotoxicity and DNA cleaving activity of Anti-DNA Autoantibody
"항-DNA 자가항체는 전신성 홍반성 낭창(SLE)의 유발에서 중요한 역할을 수행한다. 하지만 이러한 항체의 자가 면역질환에서의 잠재적인 표적물질과 병리학적인 역할은 아직 명확히 규명되어 있지 않다. 본 연구의 목적은 첫 번째로 항-DNA 자가항체의 DNA-절단 활성과 암세포와 정상세포에서의 세포독성을 분석하고 두 번째로 항체에 의한 세포사멸이 apoptosis를 통해 일어나는지 또한 어떠한 메카니즘이 관여하는지를 밝히고자 하는 것이다. "
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Pharmacological Modulation of Macrophage Cytotoxicity: Role of Protein Kinases
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987.
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Characterization of adherence, cytotoxicity and biofilm formation by Gardnerella vaginalis
Worldwide, bacterial vaginosis (BV) is the most common vaginal disorder in women of childbearing age. BV is of major clinical importance due to its ability to significantly affect pregnancy outcome and enhance the transmission and acquisition of HIV. BV is characterized by a dramatic shift in the …
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Cell-Mediated Cytotoxicity of Jensen Tumor in Sprague-Dawley Rats
… or regressors had no effect on the in vitro cytotoxicity of lymphocytes from tumor-challenged rats. Pretreatment of lymphocytes with irmnune serum, however, was shown to reduce the in vitro cytotoxicity of "immune" lymphocytes although the effect was variable and did not correlate well with …
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Proteomic Evaluation and Cytotoxicity of Red Maple (Acer rubrum) Leaves
… electrophoresis. The extract was screened for cytotoxicity activity on Michigan Cancer Foundation-7 breast cancer (MCF-7), M.D. Anderson Metastasis Breast (MDA-MB-231) cancer cell lines and anti-inflammatory activity on murine macrophage (RAW 264.7) cell line from American Type Culture …
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Nitric Oxide in the Cytotoxicity of Metronidazole Against Trichomonas Vaginalis
Using an amperometric technique (The ISO-NO meter), it was established that in aqueous solutions the rate law for auto-oxidation of NO is second order with respect to the concentration of NO, with a third order rate constant. Using a combination of electron paramagnetic resonance (EPR) techniques …
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Comparative Cytotoxicity and Genotoxicity of Drinking Water Disinfection by -Products
The quantitative rank order of the cytotoxicity and genotoxicity of the DBPs showed that brominated haloacetic acids were more genotoxic than their chlorinated analogs in mammalian cells. The difference in the responses to DBPs by bacterial and mammalian cells suggests that the relative risks based …
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Evaluation of hops essential oil cytotoxicity and anti-cryptosporidium activity
… applications. Methods. HEO and myrcene in vitro cytotoxicity (IC50) were determined in an HCT-8 intestinal cell model using flow cytometry and staining for non-viable cells with propidium iodide after treatment with controls and different concentrations of bioactives of interest (i.e. HEO and …
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