Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Cytotoxic T Lymphocyte"”.
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Cytotoxic T lymphocyte biology under the microscope
Cytotoxic T lymphocytes (CTLs) are essential agents of the adaptive immune system that seek out and destroy virally infected or cancerous cells. Incapacitate them and you become severely immunocompromised and riddled with tumours (à la prf1-/- mouse model); enhance them and you can beat previously …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
CD8+ T cells or cytotoxic T lymphocytes (CTLs) play a major role in our defense against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are …
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Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation
… various species and is involved in the homing of lymphocytes and monocytes to lymph nodes, Peyer's patches, and sites of inflammation. In the present study, we demonstrate that monoclonal antibody (mAb) 9F3, directed against murine CD44 expressed on cytotoxic T lymphocytes (CTls), can trigger the …
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Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data
Computational T-cell epitope prediction tools have been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. These tools are complements of Enzyme-linked immunosorbent spot (ELISpot) assays - a very commonly applied immunological technique …
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The identification of cytotoxic T lymphocyte (CTL) escape in a large, longitudinal subtype C HIV-1 sequence dataset
… Immunodeficiency Virus (HIV) rapidly escapes cytotoxic T-cell lymphocyte (CTL) immune responses exerted by the host. Mutation patterns and HLA associated footprints linked to viral escape have been identified, making it possible to use viral sequence data, combined with the host HLA allele …
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Impact of Cytotoxic T Lymphocyte (CTL) escape mutations in acute/Early HIV-1 Subtype C Infection on Disease Progression
… or disease by eliciting strong anti-HIV cytotoxic T lymphocyte (CTL) responses. Evolved evasion mutations that undermine host immune responses pose a major challenge to the development of such vaccines. Understanding the mechanisms that selectively favour the emergence of CTL evasion …
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Receptor-Mediated Antigen Delivery by Α<Sub>2</Sub>-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development
… may also enhance Ag-specific cytotoxic T lymphocyte (CTL) immunity. In these studies, we demonstrate that α<sub>2</sub>M*-delivered Ag (ovalbumin, OVA) enhances the production of specific <italic>in vitro</italic> and <italic>in vivo</italic> CTL responses. <br><p>Murine …
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The Development and Application of a Hemolytic Plaque Forming Cell Assay (PFC) and a Cytotoxic T-Lymphocyte Assay (CTL) in Tilapia (Oreochromis niloticus) for Immunotoxicity Risk Assessment of Environmental Contaminants
… the hemolytic plaque forming cell (PFC) and the cytotoxic T-lymphocyte (CTL) assays, quantitative indicators of antibody production and cell-mediated activity, respectively. The assays were modified in consideration of specific tilapian immune parameters, then tested using fourteen environmental …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… inhibition using monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death receptor-1 (PD-1) to enhance cytotoxic T-lymphocyte response against tumours has been used in the management of several malignancies including metastatic melanoma. Although …
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Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
The process of cytotoxic T lymphocyte (CTL) killing involves the recognition and destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. Defects in this process can lead to various autoimmune diseases and cancer. The …
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Investigation into the role of DWNN in cell death
… to the hypothesis that it may be involved in Cytotoxic T lymphocyte killing and apoptosis.
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Smac Mimetic and Combination Immunotherapy for the Treatment of Urothelial Cell Carcinoma
… with a monovalent SM, LCL161, generated T lymphocyte-dependent cures of MB49, retaining potent anti-tumour immune memory and significantly improving overall survival benefit. Separately, I report SM treatment modulates multiple components comprising the cellular adaptive immune response. …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… to RSV. These mice subsequently mounted a normal cytotoxic T lymphocyte (CTL) response and demonstrated delayed but effective viral clearance. These results provide an example of a normal and effective adaptive immune response in the absence of innate immunity mediated by MAVS and MyD88.
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Vestigial-Like 1 Is A Shared Targetable Cancer-Placenta Antigen Expressed By Pancreatic and Basal-Like Breast Cancers
<p>Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for inducing clinical regression by targeting tumor-associated antigens (TAA). To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we performed tandem mass spectrometry analysis of HLA class …
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MHC Class I Tyrosine Phosphorylation Site Y320 Augments CD8+ T Cell Priming, Effector Function, and Memory Response
… capacity to generate K<sup>b</sup>-restricted cytotoxic T lymphocyte (CTL) responses following viral infection, due (at least in part) to defects in endolysosomal trafficking of H-2K<sup>b</sup> and antigen cross-presentation by dendritic cells (DCs). In this study, we investigated whether …
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T lymphocyte responses to equid herpesviruses 1 and 4 in horses
… equine herpes virus-specific proliferative and cytotoxic T lymphocyte (CTL) responses in the blood of horses. Equine T cell blast cells stimulated from peripheral blood mononuclear cells (PBMC) with pokeweed mitogen were found to perform best as targets for CTL in "Cr release assays. CTL induced …
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Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
Autoimmunity can occur when self-reactive lymphocytes of the adaptive immune system are activated upon encounter with antigen. This can lead to the development of debilitating and potentially life-threatening autoimmune diseases such as type-1 diabetes, rheumatoid arthritis and multiple sclerosis. …
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Anti-Nucleic Acid Antibody-Mediated Cross Presentation of An Antigen and Its CD8+ T Cell Activation
Cross-presentation is important for initiating cytotoxic T lymphocyte (CTL) responses against tumors. Delivery of exogenous antigens to the cross-presentation pathway in dendritic cells using a number of different carriers has been attempted to further understand the mechanisms underlying …
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Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy
… veto activity, it enables cells to target host cytotoxic T lymphocyte (CTL) precursors specific to veto cells' antigens, selectively eliminating anti- donor T cell clones without inducing rejection. By leveraging this unique immune property, two key research aims were proposed: “Exploration of …
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