Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1199 for “"Cytotoxic"”.
-
Cytotoxic alkaloids from Tabernaemontana johnstonii
Tabernaemontana johnstonii is a medium-sized tree native to Africa. Specimens of the hardwood of the plant were procured from the United States Department of Agriculture in cooperation with the cancer chemotherapy program initiated by the National Institutes of Health (NIH). An investigation was …
-
Cytotoxic compounds from the genus Centaurea.
… and the assessment of bioactivity of cytotoxic compounds from the genus Centaurea (Family: Asteraceae alto Compositae), a large genus of about 500 species. The first three chapters deal with an introduction of natural products and Centaurea species, followed by the isolation and …
-
Formation and Pathogenicity of Cytotoxic Curli Intermediates
… investigate the formation and pathogenicity of cytotoxic curli intermediates previously unidentified in the in vitro biofilm. The identification of multiple curli conformations within the biofilm biogenesis aides in the understanding of amyloid kinetics in the enteric biofilm. Together, these …
-
Cytotoxic T lymphocyte biology under the microscope
Cytotoxic T lymphocytes (CTLs) are essential agents of the adaptive immune system that seek out and destroy virally infected or cancerous cells. Incapacitate them and you become severely immunocompromised and riddled with tumours (à la prf1-/- mouse model); enhance them and you can beat previously …
-
Synthesis of Cytotoxic Antiestrogens and Control Compounds (Nafoxidine)
… cells of breast cancer, potentially cytotoxic conjugates of an antiestrogen, desmethylnafoxidine, were prepared. Two short and efficient routes for the synthesis of a nafoxidine precursor were developed, one featuring the alpha-phenylation of a ketone and one the nickel-catalyzed …
-
Synthesis, DNA interactions and activation of novel cytotoxic anthraquinones.
… aldehydes, which should increase their cytotoxic activity due to their potential to form Schiffs bases with intracellular targets. The acetalanthraquinones were relatively poor DNA intercalators compared to the parent compound, ametantrone. The ~Tm values for YCG7, YCG8 and YCG9 were 3.6 …
-
Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
Cytotoxic T lymphocytes (CTLs) play a critical role in controlling intracellular pathogens and cancer cells, and induction of memory CTLs holds promise for developing effective vaccines against critical virus infections. However, generating memory CTLs remains a major challenge for conventional …
-
Natural and synthetic bis-indole alkaloids as cytotoxic agents
… that this compound would elicit a greater cytotoxic activity since it combined the apparently beneficial qualities of the others. Vobasivindoline was also synthesized since it contained the specified O-N-O triangular dimensions, a pharmacophore feature prevalent in many anti-leukemic drugs. …
-
The Cytotoxic Effects of Malondialdehyde on Human Lung Fibroblast Cells
Malondialdehyde (MDA) is a mutagenic and carcinogenic product of lipid peroxidation which has also been found at elevated levels in smokers. MDA reacts with nucleic acid bases to form pyrimidopurinone DNA adducts, of which 3-(2-deoxy-β-D-erythro-pentofuranosyl)pyrimidol[1,2-α]purin-10(3H)-one …
-
Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
CD8+ T cells or cytotoxic T lymphocytes (CTLs) play a major role in our defense against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are …
-
New cytotoxic natural products from North-Eastern Pacific marine invertebrates
… marine invertebrates which were found to produce cytotoxic crude extracts (ED50 against the L1210 murine leukemia cell line 5 30 pg/mL) led to the isolation of nine new and eleven previously known secondary metabolites. The structures of the novel compounds were elucidated by a combination of …
-
CYTOTOXIC EVALUATION OF SOME MANNICH BASES OF CONJUGATED STYRYL KETONES
… main objective of the present work was to design cytotoxic agents which should be highly potent and should display high preference towards cancerous cells. In order to achieve these aims, a series of compounds containing the a, (3-unsaturated ketone moiety were taken as lead molecules. The …
-
Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines.
… any of the ruthenium-based compounds exhibited cytotoxic properties. In addition, levels of vascular endothelial growth factor (VEGF) production were tested in supernate from the cancer cells treated with various ruthenium-based compounds to determine whether or not the ruthenium-based compounds …
-
Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… enrichment in IFNγ, repolarize Tregs and restore cytotoxic T cell responses against lung cancer. Next, we examined longitudinal changes in anti-tumor immunity associated with the observed decline in ICB efficacy in later-stages tumors. We found that ICB resistance at later timepoints was …
-
Signal transduction of transforming growth factor-Beta in cytotoxic T cells
Transforming-Growth-Factor-beta1 (TGF-b1) ist ein multifunktionelles Zytokin, welches insbesondere Zellwachstum und Zelldifferenzierung koordiniert. TGF-b ist vor allem dafür bekannt, Zellen des Immunsystems zu beeinflussen. TGF-b steuert zum Beispiel die Differenzierung von T-Zellen und und deren …
-
Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors
… a number of known compounds were isolated from cytotoxic fractions of the separate chloroform-soluble extracts of the stem bark, branches, and leaves of M. paniculata. Comprehensive structure elucidation techniques were used to elucidate and identify the structure of the new compounds. In …
-
Characterization of Vaccinia Virus-Induced Cytotoxic Cells in the Syrian Hamster
… on noninduced and vaccinia virus-induced hamster cytotoxic cells was studied utilizing a murine monoclonal anti-mouse Thy 1.2 antiserum ((alpha)-Thy 1.2) which detects a Thy 1.2 homologue on hamster T cells. In the hamster, (alpha)-Thy 1.2 plus complement (C') killed 100 percent thymocytes, 60-80 …
Page 1 of 60