Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Cytosolic phospholipase A2"”.
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The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… and can be a contributor of neuronal cell death. Cytosolic phospholipase A2 (cPLA2) belongs to a family of phospholipases that act as the principle producers of arachidonic acid (AA) in cells. During the process of inflammation, AA released from phospholipids is metabolized by …
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The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation
… we demonstrate that the interaction of group IVA cytosolic phospholipase A2 and ceramide-1-phosphate is crucial for production of eicosanoid synthesis in inflammation. Inflammation is a critical component of many disease states including anaphylaxis, cancer, cardiovascular disease, rheumatoid …
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Role of Ceramide-1-Phosphate as a Specific and Potent Activator of Group IVA Cytosolic Phospholipase A2 Alpha
… Release of arachidonic acid by group IVA cytosolic phospholipase A2 α (cPLA2α) is the initial rate limiting step for the production of eicosonoids in response to inflammatory mediators. Previous findings from our laboratory have demonstrated that cPLA2α is directly activated by the …
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Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines
… studies from our laboratory showed that cPLA2α may be responsible for approximately 50-60% of the PGE2 production in response to inflammatory cytokines. Thus, we hypothesized that a closely-related PLA2 is responsible for 40-50% of the PGE2 produced in response to inflammatory cytokines. To …
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Protonation and Membrane Protein Function
… outer membrane protein F (OmpF) and, (b) the Ca2+-activated membrane docking module (C2 domain) of human cytosolic phospholipase A2. Both of these biological systems were investigated using a multiscale approach, in which the results of the electrostatics calculations to determine protonation …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… myotubes induced ER stress, concurrent with the cytosolic phospholipase A2-dependent release of polyunsaturated fatty acids (PUFAs) from phosphatidylcholines (PCs). This phenotype was also observed in skeletal muscle from mouse models of diet-induced obesity and T2DM patients. …
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Mouse modifiers of intestinal tumorigenesis
… one candidate gene, the group IIA secretory phospholipase a2 (sPLA2-IIA). Only tumor prone Mom1 strains, such as B6, contain a mutation in sPLA2-IIA abolishing expression. In order to rigorously measure the effect of sPLA2-IIA on the Apdmin tumor phenotype, we have created and analyzed …
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… LTD4 via the CysLT1R can activate the enzyme cPLA2-alpha. This enzyme releases arachidonic acid, the precursor of CysLTs, from the cell membranes, upon activation. One major regulatory mechanism of GPCRs is the internalization from cell membrane upon activation. We demonstrate how LTD4 mainly …
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Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
<p>Angiotensin II (Ang II) activates cytosolic phospholipase A2α and releases arachidonic acid (AA) from tissue phospholipids. AA metabolites mediate or modulate one or more renocardiovascular effects of this peptide and have been implicated in hypertension. Since AA release is the rate limiting …
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Protective Role of Mesenchymal MyD88 Signaling Under Homeostasis and Initiation of Inflammation in the Colon
Intestinal Mesenchymal stromal cells (fibroblasts, myofibroblasts and their progenitors) have recently emerged as key players in the interplay between the microbiota and professional immune cells under homeostasis and chronic inflammation. Initiation of microbial interactions with host cells, …