Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Cytosolic Nucleic Acids"”.
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TREX1 DNASE ACTIVITY IS REGULATED BY PHOSPHORYLATION AND MACROPHAGES LACKING TREX1 HAVE IMPAIRED EFFEREOCYTOSIS
… prevent adverse immune activation by degrading cytosolic nucleic acids that would otherwise activate DNA sensors resulting in interferon production. Mutations in TREX1 cause multifactoral, systemic autoimmune diseases. Lack of TREX1 activity is not the only means of causing disease. Patients …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
… a downstream actor in the detection of non-self cytosolic nucleic acids related to viral infections and tumor conditions. The Stimulator of Interferon Genes (STING) plays a pivotal role in counteracting viral infections, independently from whether the viral genome is DNA or RNA, mounting a strong …
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Cytosolic Nucleic Acid Sensing and Senescence in a Patient-Derived Model of Progressive Multiple Sclerosis
… P-MS, highlighting the potential contribution of cytosolic nucleic acid sensing to disease pathobiology and identifying novel therapeutic targets for further investigation.
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… infection, autoimmune diseases and cancer. Cytosolic nucleic acids including DNA and RNA originate from pathogens or self-cells, which form major groups of PAMPs and DAMPs. A range of nucleic acid sensors have evolved to sense various types of nucleic acids. How different DNA-sensing …