Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Cytosine modifications"”.
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A photochemical method for the detection of cytosine modifications in DNA
Covalent modifications to DNA bases represent an important form of epigenetic information which contributes to the regulation of gene expression in many cellular processes throughout development and differentiation. Aberrant modification patterns can also signal or drive the emergence of genetic …
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Studies on approaches for sequencing cytosine modifications and the identification of their protein readers
… code, epigenetic mechanisms including covalent cytosine modifications facilitate dynamic changes in gene expression throughout development and differentiation. Such modifications are also drivers and markers of disease, earning them great academic and clinical interest. A suite of sequencing …
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Programming of cardiovascular disease: an exploration of epigenetic mechanisms
… and subsequent re-establishment of 5-methylcytosine (5mC), however this process has not previously been described for the rat. Furthermore, the involvement of more recently identified cytosine modifications; 5-hydroxymethylcytosine (5hmC), 5- formylcytosine (5fC) and 5-carboxylcytosine …
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Metabolomics and chemical library screening for antibacterial drug discovery
… enzyme. Methylation of one of the DNA bases, cytosine at the C-5 position (5-methylcytosine, 5mC) plays a crucial role in epigenetic transcriptional regulation. TET-family dioxygenases (TET1, TET2 and TET3) initiate active demethylation of 5mC. TET2 oxidizes 5mC into 5-hydroxymethylcytosine …
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… I examined CM-specific changes in DNA cytosine modifications, long non-coding RNA (lncRNA) expression and histone tail lysine methylation marks – epigenetic marks with central roles in transcriptional regulation in many biological systems. I examined how these changes correlate with …