Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Cytosine Deaminase"”.
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Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
… protein which linked endostatin (Endo) to cytosine deaminase-uracilvphosphoribosyl transferase (CD). Endo targets unique tumor endothelial cells toprovide tumor-specific antiangiogenesis activity and also carries CD to the localtumor area, where it serves nontoxic prodrug 5-fluorocytosine …
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Characterization of Genetically Modified Mesenchymal Stem Cells with a Retroviral Vector Expressing a Suicide Gene
… as a cellular vehicle to deliver a bacterial cytosine deaminase suicide gene to brain tumors. Here, we assessed whether transduction with a retroviral vector encoding cytosine deaminase gene might alter the stem cell property of mesenchymal stem cells. Mesenchymal stem cells were transduced at …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… of stem cells. MATERIALS AND METHODS: E.coli cytosine deaminase(CD) of suicide gene is enzyme that catalyzes the conversion of noncytotoxic 5-FC to the cytotoxic and radiosensitizing drug 5-FU. Cytotoxic 5-FU and its toxic metabolites can readily diffuse unto surrounding tumor cells giving CD. …
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Development of biophysical and Mass Spectrometry Assays for APOBEC3 cytosine deaminases: discovery and validation of cnvalent and non-covalent ligands
APOBEC3 enzymes are cytosine deaminase enzymes that catalyze the conversion of a cytosine base to uracil in single-stranded DNA. There are seven members of the APOBEC3 family – A3A/B/C/DE/F/G/H. APOBEC3 proteins are a part of the innate immune defense system against viral infection, and mutate the …
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Mechanism of Mismatch Repair Induced Mutagenesis in Somatic Hypermutation
… to G:U lesions by the enzyme activation induced cytosine deaminase. Left unrepaired, G:U lesions will give rise to transition mutations at G:C base pairs, but are converted to transition and transversion mutations at G:C and A:T base pairs by the paradoxical participation of the base excision …
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The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
<p>Activation-induced deaminase (AID) is a sequence-selective DNA cytosine deaminase that introduces uracils in immunoglobulin genes. This DNA mutator is required for somatic hypermutation and class switch recombination- processes involved in the affinity maturation and diversification of …
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Glioma produced periostin attracts human neural stem cells
… (F3.CD) that were retrovirally transduced with cytosine deaminase (CD) gene showed remarkable bystander effects on the glioma cells after application of the prodrug, 5-fluorocytosine (5-FC). To harness the chemotactic ability of POSTN as a tool to induce a strong bystander killer effect of brain …
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Characteristic analysis of mobility inducers for neural stem cells
… for CM-1 showed that human NSCs encoding cytosine deaminase (CD) migrated towards co-transplantation sites of NIH3T3 cells overexpressing CM-1 and glioma cells compared to only glioma cells. In addition, bystander effect by repetitive infusion of prodrug, 5-fluorocytosine (5-FC), reduced …
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The mechanism by which manganese protects Escherichia coli from hydrogen peroxide
… (PDF), threonine dehydrogenase (TDH) and cytosine deaminase (CDA). We showed that these enzymes use iron as their cofactor, and that manganese functionally replaces iron and therefore protects these enzymes when cells are stressed with H2O2. We believe iron is frequently overlooked due to …
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Diversity in APOBEC3 and CCR5 host genes and HIV-1 in a South African population
… APOBEC3G protein, which is a member of the DNA cytosine deaminase family. Entry of HIV in to the host cell is through the attachment of the viral envelope glycoprotein to the CD4 receptor, and subsequent interaction, mainly with either CCR5 or CXCR4 co-receptors. Inhibitors, such as Maraviroc, …