Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 182 for “"Cytosine"”.
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INFLAMMATION INDUCED CYTOSINE DEAMINATION DAMAGE IN CANCER ETIOLOGY
… landscape of human cancer is dominated by cytosine to thymine transition mutations, and the primary mechanism for these mutations is the deamination of cytosine and cytosine analogs to uracil and the corresponding uracil analogs. During replication, uracil and uracil analogs codes as …
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Dynamics of UV -Excited Uracil, Thymine, and Cytosine
… form. The pyrimidine bases (uracil, thymine, and cytosine) have been studied with ab initio multiple spawning molecular dynamics and high level electronic structure methods. This work has involved both gas-phase and aqueous dynamics as well as simulation of the time-resolved photoelectron …
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Regulation of transcription initiation at guanine + cytosine-rich promoters.
… of transcription initiation at guanine + cytosine-rich promoters.
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Patterns of cytosine methylation in the genome of Caenorhabditis elegans
<p>Recent large-scale comparative analysis of cytosine DNA methylation across diverse eukaryotes suggest that early features of DNA methylation present in the last common ancestor of all eukaryotes some 1.6 to 1.8 billion years ago included the methylation of gene bodies and transposable elements …
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A photochemical method for the detection of cytosine modifications in DNA
… benchmark technique for the detection of 5-methylcytosine and its oxidised derivatives, is highly destructive and greatly reduces the sequence complexity of DNA samples. These limitations are being addressed through the development of bisulfite-free sequencing methods that seek to detect modified …
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Functional consequences of cytosine methylation in mitochondrial DNA catalyzed by DNA methyltransferase 1
<p>Cytosine methylation of mitochondrial DNA (mtDNA) was first described several decades ago, but neither the mechanism generating this modification nor its functional significance was known. Because mitochondrial dysfunction is a hallmark characteristic of numerous human diseases, including …
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Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
… protein which linked endostatin (Endo) to cytosine deaminase-uracilvphosphoribosyl transferase (CD). Endo targets unique tumor endothelial cells toprovide tumor-specific antiangiogenesis activity and also carries CD to the localtumor area, where it serves nontoxic prodrug 5-fluorocytosine …
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From cytosine-tetraplexes to adenine-clusters : three crystal structures of DNA telomeric sequences
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1997.
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Modulation of RNA Cytosine-5 Methylation by Neuronal Activity and Methyl-donor Folate
… Among numerous types of RNA modifications, RNA cytosine-5 methylation (5-mrC) is recognized as an important epitranscriptomic mark that modulates mRNA transportation, stability and translation. In chapter 1, we summarize the currently available approaches to detect 5-mrC modification at global, …
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Studies on approaches for sequencing cytosine modifications and the identification of their protein readers
… code, epigenetic mechanisms including covalent cytosine modifications facilitate dynamic changes in gene expression throughout development and differentiation. Such modifications are also drivers and markers of disease, earning them great academic and clinical interest. A suite of sequencing …
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Pharmacokinetics of a novel cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown etiology
… drug (IMD) is utilized. One IMD, cytosine arabinoside (CA), has been applied to dogs with MUE due to its ability to cross the blood brain barrier, low incidence of adverse effects, and prolonged survival times reported. In spite of its increasing application for dogs with MUE, …
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The roles of DNA(cytosine-5) methyltransferase1 in carcinogenesis related to cellular factors, virus and chemicals
Infection with HPV-16 genomes which is a primary cause of cervical cancer was shown to be targeted in-vivo by CpG methylation. In a clinical study it was discovered that genomic hypomethylation of the LCR and promoter region correlated with carcinogenic progression. The HPV-16 genome could be …
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Determinants of crystal packing by nucleic acid polymers : examples of Z-DNA and cytosine-tetraplex crystal structures
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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Theoretical And Experimental Studies Of Noncovalent Metal Cation Binding And Base Pairing Interactions Of Cytosine And Modified Cytosines
… CATION BINDING AND BASE PARING INTERACTIONS OF CYTOSINE AND MODIFIED CYTOSINES</p> <p>by</p> <p>BO YANG</p> <p>December 2014</p> <p>Advisor: Professor Mary T. Rodgers</p> <p>Major: Analytical Chemistry</p> <p>Degree: Doctor of Philosophy</p> <p>Binding of metal cations to the nucleobases can …
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Development of biophysical and Mass Spectrometry Assays for APOBEC3 cytosine deaminases: discovery and validation of cnvalent and non-covalent ligands
APOBEC3 enzymes are cytosine deaminase enzymes that catalyze the conversion of a cytosine base to uracil in single-stranded DNA. There are seven members of the APOBEC3 family – A3A/B/C/DE/F/G/H. APOBEC3 proteins are a part of the innate immune defense system against viral infection, and mutate the …
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Regulation of DNA (Cytosine-5) Methyltransferase 1 in the cell cycle and its role(s) in doxorubicin-mediated micronuclei formation
The expression of DNMT1 is critical in coordinating DNMT1 activity with biological processes and therefore must be tightly regulated in the cell cycle. Several studies have shown that DNMT1 expression level is inversely correlated with p21WAF1 protein, but the exact mechanism remained unresolved. …
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An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
… viral DNA that could be adjacent host promoter Cytosine-phosphateGuanine (CpG) islands. This would activate or silence genes including tumour suppressors and result in the clinical disease phenotypes of hepatic inflammation, fibrosis and HCC that characterise chronic HBV infection. Genome-wide …
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Singlet Oxygen Oxidation of Guanine, 9-Methylguanine and Guanine-Cytosine Base Pair: Dynamics and Kinetics Revealed by Parallel Gas- and Solution-Phase Experiments and Computations
… of guanine, 9-methylguanine and guanine-cytosine base pair, from the gas-phase bare ions, through hydrated clusters, to aqueous solution. Various techniques have been adapted in the work, including <sup>1</sup>O<sub>2</sub> generation and detection, guided-ion beam tandem mass …
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