Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Cytoprotection"”.
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Role of nuclear factors kappa-B in TNFα-induced cytoprotection
Includes bibliographical references (leaves 67-81).
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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
… It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the mitochondria.
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Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection
Glutathione S-transferases (GSTs) are a multi-gene family of enzymes involved in the detoxification of a wide range of electrophilic compounds and are an integral component to antioxidant defence in the mammalian cell. Among GST, the Pi class (GSTP1) is the most prominent extrahepatic isoform in …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP …
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Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
Akt1 (protein kinase B), a serine/threonine kinase, has emerged as a critical molecule in signal transduction pathways involved in cell proliferation, growth, survival, apoptosis and glucose metabolism. A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate …
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Cellular Mechanisms of Resveratrol's Interaction with Mitochondrial Reactive Oxygen Species Metabolism
… inhibition of proliferative cell growth and cytoprotection. Thus, the induction of MnSOD is a critical step in the molecular mechanism of resveratrol. Mitochondrial morphology is a malleable property that is capable of impeding cell cycle progression and conferring resistance against stress …
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In cellulo and biophysical exploration of the role of GGMP residues of Hsp70
… the secondary and tertiary structure of DnaK. Cytoprotection of E. coli dnaK756 cells could not be recovered when cells were heterologous expressing DnaK-G. DnaK recovered the cytoprotection of the same cells as expected. Furthermore, mutations on GGMP residues adversely impacted the chaperone …
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The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs
… candidate for evaluation in models of cytoprotection.
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Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
… did not seem to be responsible for the conferred cytoprotection. In the liver, no expression of these kinases could be detected and a functional connection could not be derived. In contrast, the cAMP-dependent protein kinases were identified to promote survival. This was further supported by the …
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Comparative analysis of a chimeric Hsp70 of E. coli and Plasmodium falciparum origin relative to its wild type forms
… Hsp70 functional cycle. Hsp70s play a role in cytoprotection especially during heat stress in E. coli. Hsp70s from different organisms are thought to exhibit specialized cellular functions. As such E. coli Hsp70 (DnaK) is a molecular chaperone that is central to proteostasis in E. coli. On the …
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K(ATP) channel Kir62 subunit distribution differs between muscles and between fiber types in skeletal muscle
… for the maintenance of glucose homeostasis and cytoprotection. In skeletal muscle specifically, the channel has been shown to be involved in cell volume regulation, modulation of glucose uptake, and the prevention of fiber damage and contractile dysfunction during fatigue. The extent of the …
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The expression profile of cytoglobin in human fibrotic lung, and the protective role of cytoglobin in hypoxia and oxidative stress in vitro
… in vitro; however there was no evidence of cytoprotection with over expression of CYGB in response to these insults. There is evidence presented here that the increase in CYGB expression with fibrosis previously reported in the literature, is likely to relate to the hypoxic environment of …
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ΛΕΙΤΟΥΡΓΙΚΟΤΗΤΑ ΤΟΥ ΑΓΓΕΙΑΚΟΥ ΠΝΕΥΜΟΝΙΚΟΥ ΕΝΔΟΘΗΛΙΟΥ, IN VIVO, ΥΠΟ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΣΥΝΘΗΚΕΣ
… ACTIONS OF INDOMETHACIN APPEAR TO INVOLVE DIRECT CYTOPROTECTION RATHER THAN SHUNTING OF THE BLOOD THROUGH NORMAL OR LESS INJURED VESSELS. (SHORTENED)
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Somatic Stem Cell Populations and Studies on the Functional Role and Regulation of ABCG2
… were enriched for genes that are important in cytoprotection and cell cycle control. To confirm this observation, cell cycle analysis was performed on C2C12 myoblasts transfected with an Abcg2 overexpressing plasmid. Those cells that overexpressed Abcg2 and consequently effluxed Hoechst 33342 …
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Exploring the Molecular Mechanisms of Human Cytoglobin and its Role in Cancer
… chemotherapeutics, L46W appeared to reduce the cytoprotection. The oxidation rate of liposomes was significantly improved in the H81A mutant and slightly decreased in L46W where it mirrored the absorbance patterns of Mb. Lipid binding did not occur in L46W. Further investigation of the in-cell …
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Characterisation of the plasmodium falciparum HSP70-HSP90 organising protein
… are some of the major Hsps involved in the cytoprotection of the parasite and therefore pathogenesis of malaria. Hsp70 and Hsp90 are brought into close proximity by Hsp70-Hsp90 organising protein (Hop), allowing Hsp70 to pass partially folded substrates such as kinases to Hsp90 for further …
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The Response of Preosteoblasts to Combined Shear and Thermal Stress for Bone Tissue Engineering
… cellular proliferation, differentiation, and cytoprotection through heat shock protein induction. Despite the beneficial effects observed with individual stress on cells, there has been little focus on the potential of a combination of stresses to improve cellular response. Therefore, the aim …
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Study on the Physical and Functional Interaction between Fortilin and Peroxiredoxin I
… functions of both proteins, leading to increased cytoprotection and may be explored in future as a therapeutic target in oxidative stress-induced pathological conditions.
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Analysis of the Tumour Microenvironment in CLL
… insights into the mechanisms that underpin the cytoprotection afforded by CLL cell-endothelial cell co-culture and identifies potential new targets for disrupting these signals in vivo.
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… pre-treatment provided statistically significant cytoprotection against H2O2- and 6-hydroxydopamine- (6-OHDA) induced cell death. Further, DJ-1, a multifunctional protein, was selected for investigation with SFN, since it is highly implicated with neuronal cell health. SFN induced DJ-1 protein …
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