Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cytoplasmic Granules"”.
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The effect of Coxsackie virus A9 infection on nuclear and nucleolar proteins
… of nuclear proteins and alteration to nucleo-cytoplasmic shuttling. It was previously observed that Parechovirus genus members affect the distribution of the nuclear paraspeckle protein PS PC-1, which is an RNA-binding protein involved in splicing and RNA export. To investigate if this is a …
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
… splicing undergo dynamic reorganization into cytoplasmic granules known as U snRNA (U) bodies during metabolic stress and infection. The formation of U bodies during stress is accompanied by an overall decrease in splicing components, including the U snRNAs that are essential for mRNA …
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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… They deploy pre-formed proteases packaged within cytoplasmic granules, generate reactive oxygen species and release neutrophil extracellular traps (NETs). However, these anti-microbial strategies can also cause substantial bystander tissue injury. Infected and inflamed tissues are profoundly …
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Nucleolar Stress Due to Depletion of Nopp140 in Drosophila melanogaster
… showed that Nopp140-/- cells were deficient in cytoplasmic ribosomes, but instead contained abnormal electron dense cytoplasmic granules. Furthermore, metabolic labeling showed a significant drop in protein translation. We believe the phenotypes described here define novel intracellular …
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IAP antagonist Grim mediates cell death through divergent pathways
… Grim’s C-terminus localizes Grim to distinct cytoplasmic granules, i.e. P-bodies, where translation is repressed due to the accumulation of protein components that regulate mRNA translation or stability. Knockdown of a P-body-localized translational repressor, Me31B, largely reduced …
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TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
… work also suggests that TDP-43 associates with cytoplasmic stress granules, which are transient structures that form in response to stress. In this study, we establish sorbitol as a novel stressor that directs TDP-43 to stress granules in Hek293T cells and primary cultured glia. We quantify …
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Analysis of the organization and dynamics of proteins in cell membranes
… inflammatory mediators that are stored in cytoplasmic granules. My STMC collaborators have created two kinds of data about receptor organization and dynamics. They produce static snapshots of the organization of the receptors by fixing the cells and then labeling the receptors with …