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Showing 1 to 20 of 35 for “"Cytomegalovirus (CMV)"”.

  1. Development of a conditionally-attenuated cytomegalovirus (CMV) vaccine vector platform, and initial investigations into use of CMV as a vaccine against pandemic influenza A virus

    Hama Salih, Shirin2017

    Abstract Cytomegalovirus (CMV)-based vectors are a promising vaccine platform with an ability to induce high levels of durable, immediate, effector memory T (TEM) cell responses against their heterologous encoded pathogen target antigen. The primary focus of this thesis is centered on a hypothesis …

    plymouth Repository record

  2. Subclinical Cytomegalovirus Infection in Neonates: Its Effect on Intellectual and Auditory Functioning.

    Livingston, Mary Margaret

    Cytomegalovirus (CMV) is contracted as an intrauterine infection by the fetus during the fifth month of gestation (Medearis, 1964). One form of this virus is sometimes accompanied by a classical array of symptoms : jaundice, hepatosplenomegaly, purpura, erythroblastic or hemolytic anemia, central …

    uab Repository record

  3. Cytomegalovirus retinitis at Groote Schuur Hospital : clinical management and outcomes

    Lapere, StevenDivision of Ophthalmology2015

    … of patients who were diagnosed and treated for cytomegalovirus (CMV) retinitis at Groote Schuur Hospital over a 10 year period 2. To review and compare the treatment protocols of thirteen public hospital centres in South Africa that treat patients for CMV retinitis Design & method This is a …

    cape-town Repository record

  4. Markers of immunosenescence and oxidative stress in healthy adults

    Turner, James EdwardUniversity of Birmingham2011

    … highly prevalent and asymptomatic herpes virus, Cytomegalovirus (CMV), shapes our immune biology in two significant ways. First, CMV amplified the magnitude and kinetics of lymphocyte responses to exercise, which could potentially facilitate immune surveillance, or aggravate inflammatory …

    birmingham Repository record

  5. Comparison and Correlation of Four Methods of Measuring Immunity to Human Cytomegalovirus

    Brandt, James A.

    … to determine the presence of antibody to human Cytomegalovirus (CMV). Several more recent techniques have now been adapted for this purpose. A comparison of CMV antibody titers was made between the CF test, a commercially available enzyme-linked immunosorbent assay (ELISA), an indirect …

    loma-linda Repository record

  6. CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation

    Riddell, Natalie E.University of Birmingham2010

    … effector functions and cell differentiation. As Cytomegalovirus (CMV) infection influences CD8TL differentiation, Chapter 3 compared the mobilization of cytotoxic lymphocytes in CMV seropositive and seronegative individuals; CMV infection enhanced the stress reactivity of CD8TLs, CD4TLs and …

    birmingham Repository record

  7. Significato prognostico dell'ecografia cerebrale nei neonati con infezione congenita da citomegalovirus

    Venturi, Valentina <1970>Alma Mater Studiorum - Università di Bologna2008

    Background: Congenital cytomegalovirus (CMV) infection may lead to cerebral injury and neurodevelopmental delay. Cranial computed tomography (CT) is currently the standard imaging technique for predicting the outcome of CMV infected patients. Ultrasound (US) is a safe means to assess the extent of …

    bologna Repository record

  8. Development and Validation of Quantitative PCR Assays for DNA-Based Newborn Screening of 22q11.2 Deletion Syndrome, Spinal Muscular Atrophy, Severe Combined Immunodeficiency and Congenital Cytomegalovirus Infection

    Theriault, Mylene A.Université d'Ottawa / University of Ottawa2013

    … Combined Immunodeficiency (SCID) and Congenital Cytomegalovirus (CMV), are potential candidates for inclusion to the newborn screening panel within the next few years. The major focus of this study was to determine whether 5’-hydrolysis assays developed for the four distinct disorders with …

    ottawa-retro Repository record

  9. Investigation of Infectious Disease Associations with Cognitive Impairment using Electronic Medical Records

    Littleton, Tehya MarieThe University of Texas Medical Branch at Galveston2025

    … coronavirus disease 2019 (COVID-19), cytomegalovirus (CMV), and human immunodeficiency virus (HIV)—and subsequent cognitive impairment. On June 12, 2025, we queried the global TriNetX network for encounters containing both diagnostic codes (ICD10-CM) and confirming laboratory results …

    utmb Repository record

  10. ΧΗΜΙΚΗ ΑΝΟΣΙΑ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΕΝΕΡΓΟ ΗΠΑΤΙΤΙΔΑ ΣΕ ΣΧΕΣΗ ΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΤΟΥ HBSAG

    Κωτσοβόλου-Σώτου, ΔανάηNational and Kapodistrian University of Athens1985

    … VIRAL ANTIBODIES TO RUBELLA, MEASLES AND CYTOMEGALOVIRUS (CMV) AND NON-ORGAN SPECIFIC AUTOANTIBODIES - ANTINUCLEAR (ANA), SMOOTH MUSCLE ANTIBODIES(SMA), AND ANTIMITOCHONDRIAL ANTIBODIES (AMA) - WERE STUDIED. THE IMMUNOGLOBULINS WERE DETERMINED BY SINGLE RADIAL IMMUNODIFFUSION. THE VIRAL …

    greece Repository record

  11. HUMAN DPP4/CD26 TRANSGENIC MICE AS SURROGATE MODELS FOR MERS

    Garron, Tania MarleneThe University of Texas Medical Branch at Galveston2021

    … which is a composite promoter consisting of the cytomegalovirus (CMV)/immediate-early enhancer and the chicken β-actin promoter, containing rabbit globin splicing and polyadenylation sites, as surrogate models for MERS-CoV infections. We showed that one lineage (line 52) of Tg mice globally …

    utmb Repository record

  12. Transport in Biology, from Theory to Application

    Gong, Yishu2022

    … simulation to model placental transmission of Cytomegalovirus (CMV) with experimental data.Our methods include regularity estimates, maximal and comparison principles, probabilistic techniques, and stochastic processes. This work resulted in several conclusions: We prove quantitatively …

    duke Repository record

  13. Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model

    Marsh, Angie2014

    … induce durable immunity. Herpesviruses, such as cytomegalovirus (CMV), show much promise as viral vectors, as they establish lifelong latency with periodic reactivation, enabling persistent expression of vaccine antigens. We propose that using CMV as a lifelong reactivating HIV viral vector will …

    toronto-retro Repository record

  14. Characterisation and analysis of the NS1 gene of tick-borne encephalitis virus

    Jacobs, Susan C.Oxford Brookes University1992

    … was then cloned under the powerful constitutive cytomegalovirus (CMV) major immediate-early promoter (IE) and the CMV IEP/NS1 fragment used as the basis of an adenovirus Eta deletion mutant. The novel combination of the cytomegalovirus immediate- early promoter and the adenovirus vector produced …

    oxford-brookes Repository record

  15. Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells

    Razmi, MahyaUniversité d'Ottawa | University of Ottawa2024

    … in the field of γδ T cell biology. Because cytomegalovirus (CMV) is known to shape the αβ T cell and NK cell repertoires, I studied peripheral blood (PB) γδ T cells from both CMV-seronegative (CMV-) and CMV-seropositive (CMV+) healthy adult humans, using spectral flow cytometry. I found that …

    ottawa-retro Repository record

  16. Interdependent Regulation of Cytomegalovirus Proteins in Complex

    Bolin, Lisa L.2019

    <p>Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes significant morbidity and mortality in the immune compromised. Using the mutine cytomegalovirus (MCMV) model, we identified two genes, M140 and M141, which are determinants of macrophage tropism. Monocytes/macrophages are a …

    odu Repository record

  17. Analysis of cytomegalovirus UL97 drug resistance mutations in patients receiving Ganciclovir

    Nkosi, Nokwazi PearlDivision of Virology2018

    Introduction: Cytomegalovirus (CMV) drug resistance mutations, because of the widespread use of ganciclovir, have been widely reported in international literature, particularly in the post-transplant setting. However, a genotypic assay to detect CMV drug resistance is not available in South Africa …

    cape-town Repository record

  18. Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection

    Gokulgandhi, Mitan R.University of Missouri--Kansas City2013

    … in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, physicochemical properties such as high water solubility (170 mg/mL) and log p (-3.9) of CDF are unfavorable for …

    umkc Repository record

  19. Interactions Among Murine Cytomegalovirus US22 Family Gene Products That Influence Viral Pathogenesis

    Karabekian, Zaruhi2019

    <p>Cytomegalovirus (CMV) is a complex, ubiquitous herpesvirus that is characterized by acute, chronic, and latent infections. Monocytes-macrophages are the key target cell type involved in pathogenesis, which is most effectively studied using the murine model of CMV infection. Previously three …

    odu Repository record

  20. Social Support and Viral Reactivation in US and Foreign-Born Mexican Americans

    Rubinstein, Rebecca JudithThe University of Texas Medical Branch at Galveston2019

    … more antigens against Epstein Barr Virus (EBV), cytomegalovirus (CMV) and herpes simplex virus-1 (HSV-1), the dependent variable. Interactions between race/ethnicity and low social support were assessed, as well as the potential confounding effect of acculturation within Mexican Americans. …

    utmb Repository record

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