Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 117 for “"Cytomegalovirus"”.
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Pathogenicity of Murine Cytomegalovirus Mutants
… this study was to identified nonessential murine cytomegalovirus (MCMV) genes involved in pathogenesis in vivo. Our approach to identifyjng these genes consisted of constructing MCMV mutants, and then analyzing these mutants in vitro and in vivo. Recombinant viruses (RV) expressing the …
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Human Cytomegalovirus and the Neutrophil
Human cytomegalovirus (HCMV) is a highly prevalent opportunistic infection and a major pathogen in immune-compromised patients. The virus exhibits a wide cell tropism and is able to lytically infect virtually any cell type, with detectable gene expression and release of new virions, but not the …
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Interdependent Regulation of Cytomegalovirus Proteins in Complex
<p>Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes significant morbidity and mortality in the immune compromised. Using the mutine cytomegalovirus (MCMV) model, we identified two genes, M140 and M141, which are determinants of macrophage tropism. Monocytes/macrophages are a …
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Natural Killer Cell Responses to Human Cytomegalovirus
Human cytomegalovirus (HCMV), a member of the beta-herpesvirus family, establishes latent infection in the face of robust humoral and cell-mediated immune responses. In spite of significant efforts, the mechanisms implicated in protective immunity during HCMV infection are still not fully …
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Cytomegalovirus and herpes simplex virus infections in pregnancy
Contains fulltext : 146799.pdf (Publisher’s version ) (Open Access)
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The CD4⁺ T Cell Response to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a betaherpesvirus that infects most humans worldwide. In the healthy host, it elicits a broad immune response involving both the innate and adaptive arms of immunity, which is able to limit viral replication and prevent end-organ disease. However, like all …
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Cytomegalovirus viraemia in immunocompromised children in Cape Town
Includes bibliographical references (leaves 54-62).
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Murine Cytomegalovirus Encodes Proteins that Regulate Viral Late Transcription
<p>Human Cytomegalovirus (HCMV) is a Beta-herpesvirus that causes severe disease in immuno-compromised individuals (including AIDS patients), and is the leading viral cause of congenital birth defects. Murine Cytomegalovirus (MCMV) is the primary surrogate model for HCMV, and resembles the human …
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Analysis of human cytomegalovirus in the healthy human carrier
… leukocytes as one site of persistence of Human Cytomegalovirus (HCMV) in healthy carriers. However, the exact population of peripheral blood cells that carry HCMV and to what extent they express HCMV gene products in not known. I have examined the sites of HCMV persistence in the peripheral …
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Characterization of the Human Cytomegalovirus UL75 Late Gene Promoter
… during productive infection by the human cytomegalovirus (HCMV) occurs in an ordered and sequential manner, beginning with immediate early (IE), then early (E) and finally late (L) gene expression. Significant work has addressed the regulation of IE and E gene expression while relatively …
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Characterisation of Novel Secreted Antiviral Factors to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that infects a majority of the human population. Like other herpesviruses, HCMV readily establishes a latent infection that persists for the lifetime of the host and undergoes periodic lytic reactivation events. In healthy individuals, HCMV …
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Functional Characterisation of Protein Degradation during Human Cytomegalovirus Infection
Human cytomegalovirus (HCMV) is a ubiquitous and clinically significant herpesvirus, causing substantial morbidity and mortality in immunocompromised individuals and congenital infection in up to 1/100 pregnancies. HCMV has evolved a myriad of strategies to evade the host immune response, including …
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The Role of Viral Protein pUL21a in Human Cytomegalovirus Infection
The double-stranded DNA virus human cytomegalovirus: HCMV) is a ubiquitous human pathogen that causes severe disease in immunocompromised individuals and neonates. The biology of HCMV remains largely undefined and functions of many of the roughly 200 putative HCMV genes are still unknown. One of …
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Characterization of Murine Cytomegalovirus m142 and m143 Essential Gene Products
<p>Cytomegalovirus (CMV) is a species-specific virus belonging to the Herpesviridae family. This DNA virus causes severe disease or even death in newborns and immunosuppressed patients. Murine CMV (MCMV) provides an opportunity to study the role of various viral products in replication and …
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Analysis of two hypervariable human cytomegalovirus genes, UL146 and UL139
Human cytomegalovirus (HCMV) is a highly host-specific, ubiquitous herpesvirus that results in asymptomatic infection for the majority of those infected. However, it produces serious clinical disease in neonates and immunocompromised individuals such as transplant recipients and AIDS patients. The …
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Understanding and Exploiting Viral Protein US28 During Human Cytomegalovirus Latency
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus which infects 50-100% of humans worldwide. HCMV causes a lifelong subclinical infection in immunocompetent individuals, but is a serious cause of mortality and morbidity in the immunocompromised and in neonates. Like other herpesviruses, HCMV …
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Cytomegalovirus retinitis at Groote Schuur Hospital : clinical management and outcomes
… of patients who were diagnosed and treated for cytomegalovirus (CMV) retinitis at Groote Schuur Hospital over a 10 year period 2. To review and compare the treatment protocols of thirteen public hospital centres in South Africa that treat patients for CMV retinitis Design & method This is a …
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Construction of a Simian Immunodeficiency Virus Vaccine from Cynomolgus Macaque Cytomegalovirus
… based on herpesvirus vectors, in particular cytomegalovirus, generate unique, robust immune responses that may overcome many of the typical obstacles to an effective preventative HIV vaccine. Recent studies using a cytomegalovirus based vaccine in the rhesus macaque monkey model have …
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