Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cytolytic function"”.
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Role of Stat3 In Human Nk Cell Functions
… ligands expressed on stressed cells induce cytolytic activity of NK cells. Stimulation of NK cell proliferation and priming of NK cytolytic capability are accomplished by cytokines, which mediate their signals mainly through JAK-STAT signaling pathway. Previously, we found that K562 cells …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… was associated with increased expression of cytolytic function related genes in CD8<sup>+</sup> T cells and increased frequency of an iNOS<sup>+</sup> myeloid subset. A gene signature derived from the iNOS<sup>+</sup> myeloid cell subset correlated with clinical benefit in patients treated …
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Modeling of NK Cells in Pediatric Patients With Unusually Severe or Recurrent HSV Using High-Dimensional Flow Cytometry
… between severe infection and defects in NK cytolytic function. <em>PLCG2</em> haploinsufficient variants found in 2 HSV patients causing PLCγ2 hypophosphorylation, and loss of cytolytic function in NK cells is a novel finding recently published by Alinger et al from our lab in 2023. Prior to …
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Antigen-specific memory T cell distribution in non-lymphoid tissue
… lymph nodes to the lung where they perform their cytolytic function. After pathogen clearance, memory CD8+ T cells are generated, giving rise to long-term protection from reinfection. However, these cells are no longer detectable in the lung parenchyma six months post-infection, and cell-mediated …
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Characterization of a Novel Receptor CS1 in Human Lymphocytes; Studies in Natural Killer Cells and B-Lymphocytes
… of CS1 on human lymphocytes. The molecular and functional characterization of CS1 receptor in the natural killer (NK) cells and B lymphocytes was investigated. CS1 (CRACC, novel Ly9) is a novel member of the CD2 family receptor expressed on natural killer (NK), T cells, activated Bcells and …
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Activating The 4-1Bb Pathway For The Expansion of Tumor-Infiltrating Lymphocytes For Adoptive T-Cell Therapy For Metastatic Melanoma Patients
… expansion of CD8<sup>+</sup> TIL with increased cytolytic function and a phenotype of memory T cells with enhanced cell survival gene expression. TIL receiving 4-1BB co-stimulation during expansion also exhibited longer persistence and increased anti-tumor activity in an <em>in vivo</em> human …
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Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
… as an in vitro model for human macrophage function in mycobacterial infections. This involved evaluating the ability of differentiated U937 cells to phagocytose Mycobacterium tuberculosis, control intracellular mycobacterial growth, and present mycobacterial antigens to human HLA class …