Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Cytolysis"”.
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Functional, phenotypic and morphological studies on the mechanism of tumor cytolysis by human natural killer cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
… GSH S-transferase. Sensitization to oxidative cytolysis correlated with GSH depletion by either method by the critera of both dose-response and the time course of onset and recovery. A third approach involved inhibition of glutathione reductase (GR) with 1,3-bis(2-chloroethyl)-1-nitrosourea …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… disease progression and have been shown to exert cytolysis via antibody-dependent cellular cytotoxicity (ADCC). We postulated that if there were also relevant and detectable antibodies in MS patients that might engage these FcR-bearing γδ T-cells then this might be a purported mechanism of …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
… use glycolysis and mitochondrial respiration for cytolysis of leukemia targets, whereas unlicensed NK cells are dependent on mitochondrial respiration. We determined the metabolic pathways that are necessary for licensed and unlicensed NK cells to elicit a cytolytic response using metabolic …
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Characterisation and analysis of the NS1 gene of tick-borne encephalitis virus
… challenge by NS1 is due to complement mediated cytolysis of infected cells. The ability of NS1 to protect mice deficient in the terminal lytic pathway of the complement cascade, implied that complement mediated cytolysis is not the major mechanism by which protection is elicited. This research …
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Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
… their sensitivity to non-antigen specific cytolysis mediated by NK or LAK cells. Following infection with M. tuberculosis, U937 target cells were lysed by M. tuberculosis-primed CTLs from HLA class I-matched donors in an antigen-specific manner and with a similar efficiency to autologous …
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Staphylococcus aureus Panton-Valentine leukocidin (PVL) alters human neutrophil viability and function
… the plasma membrane of PMNs leads ultimately to cytolysis. However, this hypothesis has not been tested and previous studies indicate that levels of PVL <i>in vivo</i> are likely insufficient to cause host cell lysis. On the other hand, sublytic concentrations of PVL prime neutrophils for …
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Staphylococcus aureus Panton-Valentine leukocidin (PVL) alters human neutrophil viability and function
… the plasma membrane of PMNs leads ultimately to cytolysis. However, this hypothesis has not been tested and previous studies indicate that levels of PVL <i>in vivo</i> are likely insufficient to cause host cell lysis. On the other hand, sublytic concentrations of PVL prime neutrophils for …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… induce cytokine secretion, proliferation, and cytolysis upon engagement. Most importantly, the RMTC were able to specifically kill antigen-specific cells both in vitro and in vivo and prevent EAE disease. We hypothesize that the humanized chimeric receptors could be used as a therapeutic …
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T-Cell Treatments For Solid and Hematological Tumors
… antigen presenting cells (aAPC). Enhanced cytolysis of CD19<sup>+</sup> leukemia was observed by CAR<sup>+</sup> gamma/delta T cells compared to CAR<sup>neg</sup> gamma/delta T cells, and leukemia xenografts were significantly reduced compared to control mice <em>in vivo</em>. The third …
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Differentiation and activation of functionally distinct macrophage populations by CSF-1 and GM-CSF
… but GM-CSF-derived BMDM were inhibited 33% for cytolysis of K562 tumor cells. Interestingly, GM-CSF-derived BMDM were much less sensitive than CSF-1-derived BMDM for PGE$\sb2$, but not cAMP-mediated inhibition of TNF-$\alpha$. Arginine depletion blocked NO$\sb2\sp-$ production by both BMDM …
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Large-Scale Applications of Multi-Reference Methods in Chemistry and Development of a Multi-Reference Moller-Plesset Perturbation Theory Program
… diradicals and causes DNA cleavage and finally cytolysis. Computations on model systems performed in the present work show the influence of structural features on the mode of action and the efficacy of this antitumor-antibiotic. The cyclization of systems related to the enyne-cumulene framework …
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High-Throughput Single-Cell Functional and Molecular Profiling of Immune Cells in Cancer Immunotherapy
… to those without IFN-γ secretion, suggesting cytolysis to be the dominant determinant of the interaction behavior and that killing enables faster synapse termination. In addition, tracking the speed of these cells by TIMING indicated that serial killer T cells may be identified based on their …
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Lymphodepletion with repeated cycles of alemtuzumab and secondary autoimmunity after alemtuzumab treatment of relapsing-remitting multiple sclerosis
… although CD52-negative clones are not seen. In a cytolysis assay, reduced CD52 density was shown to correlate with reduced susceptibility to alemtuzumab. In addition, activated proliferating T lymphocytes, as observed after treatment, downregulated CD52 expression in a gene expression assay and …
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Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity
… effects on the host defense. In contrast, cytolysis by Tc1c cells in the absence of IFN-g production might represent the protective class of response. Further studies in the field of Tc1 effector cell diversity should lead to valuable insights for management of infections and developing …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
… blocked IFN-γ and TNF-α secretion as well as cytolysis of target cells in a dose-dependent manner. However, MAP3K8/Tpl2 deficient murine CTLs did not exhibit any functional deficiency either in vitro or in vivo. Furthermore, we have found that the Tpl2 inhibitor did not block IFN-γ and TNF-α …
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Cord Blood-Derived Invariant Natural Killer T Cells as a Platform for Allogeneic Chimeric Antigen Receptor Cell Therapy
… production after 8F4CAR mediated leukemia cytolysis, which is consistent with iNKTCR mediated stimulation of parental CB-iNKT cells. Importantly, CB-8F4CAR-iNKT cells display anti-leukemic activity <em>in vivo</em>. This thesis supports the idea that CB-iNKT cells can be an effective …
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Genetic determinants of cell sensitization to parvovirus H-1-induced activation of non-apoptotic death pathways
… to render REFs permissive to H-1PV-mediated cytolysis. While the virus accomplishes cytosuppression of ras*/p53dn-transformed REFs by activating classical apoptosis, it triggers in all the other transfectants a non-apoptotic death pathway characterized by the cytosolic accumulation of …
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Immune biomarkers predicting clinical outcomes for major trauma patients
… categories, these are; metabolic disruption, cytolysis, inhibitory cytokines such as interleukin-35 (IL-35), IL-10, and transforming growth factor- (TGF-), and finally, suppression by modulation of dendritic cell function or maturation. The correlation between T regs and IL-6 also provide …
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