Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Cytokine therapy"”.
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Precision Cytokine Therapy: Engineering and Delivery of CD8- and CAR-Tropic Interleukin-2 Variants
… to develop novel therapeutic approaches. Immunotherapy represents one potential strategy, although the unique immune-privileged status of the brain poses a major challenge to its success. Immune privilege refers to the limited ability of the central nervous system (CNS) to generate strong immune …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
… low response percentages; however, recent cytokine therapy experiments have produced promising results. A novel adenovirus, Ad.5/3-mda-7, has been synthesized to efficiently infect renal cancer cells with the mda-7 gene. This gene encodes for the cytokine MDA-7/IL-24 that has the ability to …
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A materials-based approach for localized delivery of cancer immunotherapy
Cancer immunotherapy provides a promising new alternative to traditional cancer treatment modalities such as chemotherapy and radiation. However, even the most effective therapies only show benefit in a subset of patients when used alone and so, combination therapy may be critical to maximizing …
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Retinoide in der Therapie des metastasierten Nierenzellkarzinoms : Untersuchungen am Modell multizellulärer Tumorsphäroide
… treatment strategies like radiation and chemotherapy. Through means of cytokine immunotherapy, by which the interactions between the organism and tumor cells are to be modified by the therapeutically administration of intercellular messenger agents, the progression of disease can be positively …
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T cell mediated combination immunotherapy
Immunotherapy is a broad treatment strategy that harnesses the immune system to fight off a particular condition or disease. Cancer immunotherapy is the specific application of agents designed to interact or stimulate the immune system to fight off tumors. Treatments as diverse as passive antibody …
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Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
Cancer immunotherapy, such as immune checkpoint inhibitors, Chimeric Antigen Receptor (CAR) T therapy, and cytokine therapy, have achieved successful improvement in extending survival in some patients. However, the immunosuppressive environment of solid tumors substantially compromises therapeutic …
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Engineering cytokine immunotherapies via cell surface targeting
Cancer immunotherapy targets immune cells to trigger a highly specific, long-lasting anti-tumor response. With the clinical success of immune checkpoint blockade and the development of promising next-generation agents, immunotherapy is steadily growing as a key pillar of the oncology clinic …
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Improving methods for cytokine immunotherapy of cancer
Cytokine therapy can activate potent antitumor responses, yet collateral toxicity often limits dosages. Although immunocytokines have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated by attempted tumor targeting. In the first …
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Engineering Tumor-Localized Therapies for Cancer – from Antioxidant Enzymes to Cytokines and Radiation Therapy
Surgery, radiation therapy, and chemotherapy are mainstays of cancer treatment, treating cancer by directly removing or killing cancer cells. In recent decades, alternative treatments such as targeted therapy and immunotherapy have revolutionized the treatment of cancer, improving tumor control and …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… Fcgamma receptor IIIa (FcgammaRIIIa) and various cytokine receptors, which can be activated upon encountering antibody-coated targets and cytokines in the tumor microenvironment. Previous work from our group reported a significant association between elevated IFN-gamma levels in patients receiving …
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Gene Therapy Using Tet-Repressor System to Modulate Prostate Tumor Microenvironment
… therapies at this stage. Therefore immunotherapy seems to be a promising approach to treat metastatic prostate cancer through enhancing tumor-specific T cell responses. In this regard, there is a growing interest in the generation of fully competent dendritic cells (DCs) that are known to …
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Novel insights in the serodiagnosis and pathogenesis of swine influenza
… waren ten eerste om in detail de respons van cytokines en acute fase eiwitten na een experimentele infectie met varkensinfluenza te beschrijven en het nagaan van de rol van interferon- (IFN-) in de pathogenese van varkensinfluenza. In een tweede deel van het onderzoek werd de bruikbaarheid …