Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Cytokine signalling 3 (SOCS3)"”.
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 Lys residues …
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The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis
… homeostasis. There are several conserved signalling pathways that are responsible for the proliferation of intestinal cells. Suppressor of cytokine signalling 3 (SOCS3) is produced upon activation of the Janus kinase/Signal transducer and activator of transcription (Jak/Stat) pathway and …
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Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines: IL-6 and leptin in endothelial cells
… and reducing pro-inflammatory effects of cytokines. Although the protective effects of cAMP elevation on limiting endothelial dysfunction have been well documented, the exact molecular mechanisms remain unclear. Using two endothelial cell types, namely human umbilical vein endothelial …
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Mechanisms of microglia induced retinal degeneration
… Microglia can be activated by inflammatory cytokines through the JAK/STAT pathway of cytokine receptors. Suppressor of cytokine signalling 3 (SOCS3) negatively regulates the JAK/STAT pathway. In this study, a mouse strain with the deletion of two inhibitory genes (CX3CR1 and SOCS3) in …
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Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
To avoid overshooting cytokine signalling with possible pathological consequences, the duration as well as the intensity of the activated signal transduction pathways are tightly regulated. The importance of the feedback inhibitor suppressor of cytokine signalling 3 (SOCS3) in inhibition of the …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
… of JAK kinases resulting in Ras/Erk-mediated signalling and activation of STAT transcription factors, particularly STAT3. Within the present studies the role of the Interleukin-6 (IL-6) receptor gp130 in hepatocytes was investigated in terms of liver regeneration, liver dependent iron …