Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 294 for “"Cytokine production"”.
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Ethanol Impairs Mechanisms of Macrophage Phagocytosis and Cytokine Production
… decreased <italic>ex vivo</italic> TNFα production by splenic and alveolar macrophages (AMs). Interestingly, the higher dose of ethanol resulted in sustained suppression of LPS-induced TNFα production at 3 and 6 hours post ethanol administration, as well as decreased IL-6 and IL-12 …
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Integrin-ligand interactions and cytokine production by monocytic cells
… receptors is important in the regulation of cytokine production by monocytic cells. Most monocytic cells will express a combination of the different CD23-binding integrins simultaneously and, therefore, the cytokine output of that cell will be the net result of the interaction of CD23 with a …
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Mevalonate metabolites contribute to granulocyte chemotaxis, cytokine production, and sepsis mortality
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Dietary fatty acids modulate inflammatory cytokine production through activation of MAP kinases
… on MAP hnase signaling pathways and cytolune production in macrophages following achvation of these cells through these TLRs Macrophages are key cells involved in activation of innate immune responses. Ths study used the J774 munne macrophage cell line as a model. The results demonstrate that …
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The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
… specifically with respect to inflammatory cytokine production. Endothelial cells, exposed to various glucose levels, and MALAT1 knockout mice and controls, with or without streptozotocin-induced diabetes were examined. Endothelial cells cultured with high glucose, and renal and cardiac …
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Soy Isoflavone Supplementation Does Not Alter Lymphocyte Proliferation and Cytokine Production In Postmenopausal Women
A growing body of evidence has demonstrated that soy isoflavone consumption may protect against the development of various chronic diseases. This protection could be linked to isoflavone-induced alterations in immune function. However, recent in vitro and animal studies suggest that soy isoflavones …
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CD46-mediated signals in the regulation of T-cell cytokine production and intestinal wound healing
… protein CD46 regulates the key T helper type 1 cytokine IFN-y and the canonical immunosuppressive cytokine IL-10. The production of both IFN-y and IL-10 is shown to be temporally regulated by TCR and CD46 signals in CD4+ T cells in an IL-2-dependent fashion and is shown to be defective in …
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Effects of Antioxidant Supplementation with Vitamin E and Selenium on Cytokine Production in Mice Infected with Trypanosoma Cruzi
… In addition, the synthesis of many regulatory cytokines is known to be influenced by changes in the cellular oxidant/antioxidant balance. The present study was performed to determine the impact of the antioxidants vitamin E and selenium on the T helper (Th) 1/Th2 cytokine balance during …
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The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
… suitable tocolytic targets. In addition, ten cytokines in human cervico-vaginal fluid (CVF) were measured according to interval to labour to test their suitability as labour onset predictors, with a view to developing a test to determine women at risk of preterm labour. Prostanoid analysis was …
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The Suppressive Mechanisms of TIM3 on T Cell Cytokine Production and The Anti-Tumor Effect of TIM3-Pathway Inhibition
… mechanisms underlying down-regulation of cytokine production by human TIM3 expression in T cells and the effect of expression of Tim3-hIg, mouse Tim3 pathway blocker, on tumor growth in mice. First, reduced expression of IL-2 and IFN-γ was demonstrated in both primary CD4+ T cells with …
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Analysis of the Immunomodulatory Properties of Mycobacterium Cell Wall Fraction on the Cytokine Production of Peripheral Blood Mononuclear Cells of Healthy Dogs
… chain reaction (qRT-PCR) for quantifying cytokine protein and mRNA transcripts, respectively. PBMCs were isolated from eight healthy dogs and cells were cultured with MCWF. A significant increase of interleukin (IL)-10 mRNA was detected at all time points for all concentrations of MCWF …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… gapmeRs reduced Mtb growth and anti-inflammatory cytokine production mediated by increased apoptosis, nitrite and pro-inflammatory cytokine production in IL-4/IL-13 prestimulated mouse macrophages. Whereas knockdown of lncRNA-125 in IFN-γ pre-stimulated mouse macrophages favoured Mtb growth and …
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Diverse Immune Responses Mediated by Beta-Adrenergic and Corticotropin-Releasing Hormone Receptors in a Model of Pneumococcal sepsis
… play a pivotal role in antigen presentation and cytokine production, influencing both innate and adaptive immunity. Initial studies examined the potential immunomodulatory effect of epinephrine and CRH on DC cytokine production in response to the bacterial pathogenic ligand, lipopolysaccharide …
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Understanding the Role of Mitochondria in Driving Antiviral Inflammatory Responses
… was associated with high levels of inflammatory cytokine production dependent on glycolysis for ATP production. TLR3 engagement was associated with a robust type I IFN response, requiring sustained OXPHOS activity for energy production. We found mitochondria superoxide production (mtROS) had …
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Correlates of protective immunity in individuals who are exposed to Hepatitis C but appear uninfected
… (IL)-2 ELISPOT assay, and a multiplex in vitro cytokine production assay were then used to evaluate HCV-specific cellular immune responses in three cohorts of seronegative subjects at high-risk of exposure to HCV – babies born to infected mothers, multiply-transfused subjects with thalassaemia, …
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The innate response to fungal infection
… resulting in pro and anti-inflammatory cytokine production.<br/>Following Dectin-1 activation, I show that blocking SYK activity with SYK inhibitor II<br/>prevents MAPK and NF?B signalling, causing a reduction in both pro and antiinflammatory cytokine production. However, the clinically …
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