Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Cytokine Analysis"”.
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Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
… RNA sequencing, bronchoalveolar lavage (BAL) cytokine profiling, and immune cell phenotyping revealed that female Arnt-a transgenic mice exhibited attenuated neutrophilic inflammation, reduced proinflammatory cytokine expression, and accumulation of FOXP3+ regulatory T cells. In contrast, …
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Lewy Body Dementia and the Role of Inflammation
… 10 matched control subjects underwent peripheral cytokine analysis. Results: The clinical prevalence rate of LBD was low compared to the known pathology rates, with delays identified in the diagnosis of DLB compared to other dementia subtypes. Delays were also seen between the onset of dementia …
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Immunomodulatory effects of the filarial nematode product, ES-62, and phosphorylcholine-based small molecule analogues S3 and S5 in experimental autoimmune encephalomyelitis
… T cells and macrophages and their associated cytokine cells with episodes of demyelination. The filarial nematode excretory secretory product ES-62 has shown anti-inflammatory activity in related autoimmune diseases and, along with small molecule derivatives (SMAs), could have therapeutic …
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The effect of nfa1 accination against Naeglearia fowleri infection
… by fluorescent microscopy and Western blotting analysis. The viral vector systems effectively delivered the nfa1 gene to the target cells and expressed the Nfa1 protein within the target cells. To evaluate immune responses of nfa1-vaccinated mice, BALB/c mice were intranasally vaccinated with …
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Development of silicon photonic microring resonator biosensors for multiplexed cytokine assays and in vitro diagnostics
… traditional sensing technologies for biomarker analysis and fundamental biological studies (i.e. enzyme-linked immunosorbent assays, real-time polymerase chain reaction, etc.) rely on single-parameter measurements, it has become increasingly clear that the inherent complexity of many human …
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Thermal Ablation Alters The Tumor Microenvironment Activating A Robust Immune Response.
… patients treated with ablation. Gene microarray analysis and immunohistochemistry (IHC) for presence of immune cell subtypes were performed on the tissue samples. Prospectively, blood was collected from patients 13 patients who underwent renal ablation for renal cell carcinoma for stage T1a (less …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… and profiled its microenvironment through cytokine analysis. Finally, we developed a novel protocol to cryopreserve iPSC-aCMs that retains their drug responses, and we discovered a role of Ephrin and Connexin signaling by cardiac fibroblasts for iPSC-aCM maturation and organization. …
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Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
… despite causing attenuation of pro-inflammatory cytokine production. When MPLA was administered after a CLP core temperature was not preserved, but bacterial clearance was still enhanced. Concentrations of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6, that are regulated through the …
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
<p>Previously, we demonstrated via RNA-sequencing analysis of murine intracranial melanoma tumors that pharmacologic inhibition of oxidative phosphorylation (OXPHOS) results in increased expression of genes consistent with activated anti-tumor immune responses. <strong>The central hypothesis of …
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Investigation of the Efficacy of a Novel CsA Formulation Alone or in Combination with Cell Therapy in a Humanised Mouse Model of GvHD
… IFNγ signalling in MSC through suppressor of cytokine signaling 1 (SOCS1) inhibition resulting in the enhancement of MSCγ suppression of CD3+ T cells and increased indoleamine 2,3-deoxygenase (IDO). For the first time, we have shown that a novel CsA formulation, SmPill® provided safe and …
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Role of the systemic inflammatory response in the clinical and biological features of incurable cancer and cachexia
… examined the relationship between circulating cytokines and symptoms in incurable cancer. The second review, described in chapter three, examined the relationship between circulating cytokines and cachexia/ weight loss in incurable cancer. Quality of studies was assessed in both reviews using a …
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Perinatal high-fat diet and Bisphenol A: effects on behavior, gene expression and neuroanatomy in the medial prefrontal cortex
… was collected from pups for gene expression and cytokine analysis. Littermates were observed for changes in periadolescent play behavior from postnatal day 26- 40, elevated plus maze (EPM) and social recognition in adulthood. Further, the cortex was collected in adulthood to assess gene …
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Caracterização da microbiota intestinal, perfil inflamatório e integridade da barreira gastrointestinal de crianças diagnosticadas com transtorno do espectro autista
… sequencing and antimicrobial resistance gene analysis. Relative abundance, alpha diversity, and beta diversity analyses were performed to characterize the microbiota and resistance genes, along with differential relative abundance analysis. Zonulin, Claudin, and Occludin concentrations were …
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Tobacco/HIV-1-Induced Myeloid Cell-Derived Extracellular Vesicles in HIV-1 Pathogenesis
… to EVs, as well as subjected to downstream analysis (p24 ELISA, LDH cytotoxicity assay, DNA damage assay, rtPCR, western blot, cytokine analysis). </p> <p><strong>Results. </strong>Initially, we demonstrated that CSC reduced total protein and antioxidant capacity in EVs derived from …
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Multi-Scale Modelling of Host-Microbe Interactions: From Cell Membranes to Multi-Cellular Gut Models
… resistance. The models and devices, supported by cytokine and metabolomics analysis, are used to study how faecal matter supernatants from patients with irritable bowel syndrome affect intestinal barrier integrity, compared to faecal matter supernatants from their household controls. Not only is …
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Analysing M. avium-macrophage interactions and establishing a long-term infection in a novel and realistic model of lung alveolar macrophages, Max Planck Institute Cells
… at a more rapid rate than the rough. In the analysis of cytokines, both the rough and the smooth strain appeared to induce IL-6 levels that were comparable to non-infected cells which could indicate a mechanism of survival.
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The effects of 2’-fucosyllactose and Bifidobacterium longum subspecies infantis supplementation on growth, intestinal development and immune development and function in piglets
… lymph node (MLN) immune cell population and cytokine production in response to ex vivo stimulation in addition to serum cytokines and immunoglobulins. At sacrifice, blood was taken for serum cytokine analysis and immune cells from blood and mesenteric lymph nodes were isolated for ex vivo …
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The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice
… infection for multiparameter flow cytometry analysis. We compared P. berghei and P. chabaudi, their effects on B cells, effector and memory T cells and the outcome on BCG-induced protective efficacy against M. tuberculosis H37Rv infection by subsequent aerosol challenge. P. berghei induced a …
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An investigation of liver blood flow in systemic inflammation
… of systemic inflammation. The pro-inflammatory cytokines such as IL-6 mediate inflammation. These are secreted by activated macrophages of which 80% are resident in the liver as Kupffer cells. Cytokines act on the liver hepatocytes causing them to produce proteins. Plasma proteins that change in …