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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 23 for “"Cytokine/chemokine"”.

  1. Lymphatic Dysfunction and Associated Systemic Inflammation In Lymphedema, Assessed By Nirf-Li Imaging and Plasma Cytokine/Chemokine Analysis

    Vang, Anna, <p>0000-0001-5656-5906</p>2023

    … at 6- and 12-months post-RT). Fourteen plasma cytokine/chemokine levels were assessed at each time point using a MILLIPLEXMAP human cytokine/chemokine magnetic bead panel. Plasma cytokine/chemokine levels in patients with ≥5% perometric arm swelling at 12 months post-RT were compared to those …

    uthsc Repository record

  2. Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury

    Raczynski, Arkadiusz R. (Arkadiusz Roland)Massachusetts Institute of Technology2011

    … with distinct circulating and tissue specific cytokine/chemokine profiles. Using Acetaminophen (APAP), a widely used analgesic and well-characterized hepatotoxin, we evaluated liver responses in isolation and in the context of host inflammation to gain insight into the role of live bacterial …

    mit Repository record

  3. Quantitative analysis of TLR-4-mediated cell responses in murine macrophages

    Wu, RongcongMassachusetts Institute of Technology2008

    … of downstream signaling pathways to regulate cytokine/chemokine release, endotoxin tolerance and apoptosis, which have been suggested to directly or indirectly participate in the regulation of innate and adaptive immune responses. However, little is known about their detailed signal-response …

    mit Repository record

  4. Mechanism of action of AexU, a new type III secretion system effector from an emerging human pathogen Aeromonas hydrophila

    Johanna Carolina SierraThe University of Texas Medical Branch2010

    … increase in the production of proinflammatory cytokines/chemokines was noted. These data indicated that either such a mutated AexU is a potent inducer of them or that AexU possesses yet another unknown activity that is modulated by ADPRT and GAP activities and results in this aberrant …

    utmb Repository record

  5. Investigating the negative regulatory role of neurogranin in IgE-mediated mast cell activation

    Hunter, KatieBrock University2023

    … essential for degranulation and pro-inflammatory cytokine/chemokine production, processes that require the Ca2+/calmodulin (CaM)-dependent phosphatase, calcineurin. Neurogranin is a protein that regulates Ca2+-mediated signaling pathways by binding and sequestering of CaM, subsequently acting as a …

    brock Repository record

  6. New virulence mechanisms in Yersinia pestis, the plague (Black Death)-causing bacterium: A re-emerging and bioterror pathogen

    Stacy Leona AgarThe University of Texas Medical Branch2009

    … the LD50 dose, bacterial dissemination, cytokine/chemokine production, and tissue damage over a 72-h course of infection. Plague in mice and rats mimics disease in humans and understanding disease progression in these models will facilitate a better understanding of disease in humans.\r\n

    utmb Repository record

  7. Microenvironment-Induced Pten Loss By Exosomal Microrna Primes Brain Metastasis Outgrowth

    Zhang, Lin2016

    … tumor cells leads to an increased secretion of cytokine chemokine (C-C motif) ligand 2 (CCL2), which recruits Iba1+ myeloid cells that reciprocally enhance outgrowth of brain metastatic tumor cells via enhanced proliferation and reduced apoptosis. Our findings demonstrate a remarkable plasticity …

    uthsc Repository record

  8. Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses

    Dawes, Brian EThe University of Texas Medical Branch at Galveston

    … to LACV infection with strong proinflammatory cytokines and chemokines. In contrast, NiV replicated in both neurons and astrocytes, inhibited inflammatory cytokine/chemokine production, and produced delayed interferon-β responses. Interferon-β was shown to significantly reduce viral titer, …

    utmb Repository record

  9. The Role of ASK1 in Allergen-mediated Mast Cell Signaling and Activation-dependent Inflammatory Responses

    Rouillard, Melissa MBrock University2022

    … in BMMCs, such as protein/mRNA expression, cytokine/chemokine secretion, receptor expression, and cell viability were also investigated. Through western blotting, our results show that GS-444217 does not alter JNK, p38, ERK, or ASK1 protein levels. Phosphorylation of ASK1 could not be …

    brock Repository record

  10. Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?

    Janas, PiotrThe University of Edinburgh2023

    … subsequent microbial stimuli. Despite promising cytokine/chemokine gene expression results of isolated murine AECs, I was unable to definitely confirm RSV-induced changes in response to subsequent stimulation at the transcriptional or protein level. ivNevertheless, using the murine model, I …

    edinburgh Repository record

  11. The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis

    Law, Brittany Ann

    … was detected. An increase in inflammatory cytokine/chemokine mRNA (interleukin-33 (IL-33), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-alpha (TNF-α)) was observed in cardiac fibroblasts treated with ethanol.</p>

    south-carolina Repository record

  12. Dissecting the anti-allergic potential of carnosic acid during IgE and IL-33-mediated mast cell activation

    Robert W.E. CrozierBrock University2025

    … production and release of pro-inflammatory cytokine and chemokines. As a result of mast cells being the main perpetrators of the inflammatory responses associated with allergy, identifying novel mast cell stabilizing compounds is an area of intense investigation worldwide in an effort to …

    brock Repository record

  13. Enhancing T-Cell Responses to Vaccination of HIV-1 infected Subjects on Antiretroviral Therapy

    Ramirez, Lorenzo Antonio2014

    … infected subjects, despite ART, have an altered cytokine/chemokine environment. Thereby it is important to explore whether targeting the cytokine milieu can lead to improvements in responses to vaccination in these individuals. We specifically found that the pro-inflammatory chemokine IP-10 was …

    penn Repository record

  14. Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization

    Guo, Xizhi2019

    … with immune cell migration/activation and cytokine/chemokine release, can be induced after infections. Recent studies have painted a complex picture of viral clearance and tissue repair in adults. The immune responses in neonatal influenza infections and the potential methods to engineer …

    tenn-hsc Repository record

  15. Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins

    Ahmed, Suaad M.National University of Ireland Maynooth2012

    … signalling pathways that mediate proinflammatory cytokine and IFN responses following their activation by doubled-stranded RNA and LPS, respectively. In the present study, we sought to investigate the novel proteins and pathways that serve to modulate the functionality of TRIF. To this end, …

    maynooth Repository record

  16. Protective Role of Mesenchymal MyD88 Signaling Under Homeostasis and Initiation of Inflammation in the Colon

    Uribe, GabrielaThe University of Texas Medical Branch at Galveston2022

    … by using RNAseq, qRT-PCR, ELISA, western blot, cytokine/chemokine multiplex array, flow cytometry, and confocal microscopy. In our first aim, I found that deletion of MyD88 within mesenchymal stromal cells in vivo resulted in inflammatory changes and increased fibrosis within the colonic mucosa …

    utmb Repository record

  17. Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model

    Wood, Connor2020

    … and the resulting effector molecules such as cytokines, chemokines and type I IFNs. MPI macrophages are susceptible to IAV infection but this results abortive replication, following established understandings. However, MPI macrophages are much more sensitive to influenza infection than non-AM …

    plymouth Repository record

  18. Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes

    Abudalo, RawanQueen's University Belfast2020

    … were treated with high glucose which induced cytokine/chemokine expression, dependent upon NF-κB as a prototypical proinflammatory mediator associated with macrophages infiltration and adhesion, effects which were reversed by liraglutide. Furthermore, liraglutide attenuated fibroblast …

    qu-belfast Repository record

  19. The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation

    Sullivan, Ryan Patrick2015

    … pathways - direct cytotoxicity, and indirect cytokine/chemokine production (e.g. IFN-g), which shapes the subsequent adaptive immune response. The importance of this role of NK cells in human health is highlighted by the recurrence of herpesvirus infections in NK-deficient patients, as well as …

    wustl Repository record

  20. HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation

    Shah, AnkitUniversity of Missouri--Kansas City2014

    … increased expression of various proinflammatory cytokines. Additionally, it has been well documented that various drugs of abuse can exacerbate HAND, but the mechanism by which this occurs is still poorly understood. The present study was based on the central hypothesis that HIV-1 gp120 and …

    umkc Repository record

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