Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1662 for “"Cytokine"”.
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Cytokine Dysregulation Promotes HPV Persistence
… The inability to maintain the appropriate cytokine milieu in the cervical mucosa has been implicated in HPV persistence. The switch from a predominantly Type 1 cytokine response to a predominantly Type 2 cytokine response is well-documented in advanced cervical lesions and cervical cancer …
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Cytokine secretion in glioblastoma patients
… capable of releasing various immunosuppressive cytokines, which inhibit the cytotoxic function of T cells. Cytokines are multifunctional pleiotropic proteins, which are involved in intercellular communication and cellular activation, and they may exert their effects in the CNS both directly and …
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Structural analysis of cytokine signaling modulators
<p>The N-linked glycans attached to cytokine receptors modulate signal transduction by interacting with galectin-3 and generating a cell surface lattice. This opposes constitutive endocytosis and reduces the thresholds for cytokine signaling. The preferred ligands for galectin-3 are the …
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Engineering Intratumoral Cytokine Therapies for Cancer
… anti-tumor immunity for some cancer patients. Cytokines are key signaling proteins that help activate and sustain critical immune cells during this process. Unfortunately, traditional cytokine therapies suffer from low efficacy and high systemic toxicity. As one strategy to improve therapeutic …
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CYTOKINE CONTROL OF GLIOMA ADHESION AND MIGRATION
… can influence tumor progression by secreting cytokines such as Tumor Necrosis Factor alpha (TNF-α). In this study, we show that patient-derived glioma spheres undergo morphological changes in response to TNF‑α that are associated with changes in migration behavior in vitro. These morphological …
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Characterisation of cytokine secretion in malignant gliomas
Cytokines are proteins produced by cells of the immune system. The working hypothesis of the thesis is to show that the lymphocytes and glial cells in Glioblastoma Multiformae patients have an altered pattern of secretion of cytokines compared with low-grade and non-cancerous patients. Lymphocyte …
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Engineering cytokine immunotherapies via cell surface targeting
… alongside surgery, radiation, and chemotherapy. Cytokines, endogenous regulators of immune responses, have long been promising immunotherapy candidates due to their innate ability to modulate lymphocyte behavior. However, translation of cytokines as systemically administered immunotherapies has …
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Layer-by-Layer Nanoparticles for Cytokine Delivery
… such as ovarian cancer (OC). The action of cytokines in the tumor microenvironment (TME) is key to regulating immune responses, but dose-limiting toxicities limit the application of cytokines in cancer therapy. One promising approach to improve treatment with cytokines are nanoparticles …
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Improving methods for cytokine immunotherapy of cancer
Cytokine therapy can activate potent antitumor responses, yet collateral toxicity often limits dosages. Although immunocytokines have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated by attempted tumor targeting. In the first …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… types. Hematopoietic growth factors, so called cytokines, have previously been demonstrated to be important for the survival and proliferation of committed progenitor cells and development of different blood cell lineages. However, their potential role in regulating HSCs remains to a large …
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Regulation of cytokine and chemokine production in macrophages
… signaling pathways regulating production of cytokines and chemokines in response to PRR agonists.<br/>Interleukin (IL)-10 is a potent anti-inflammatory cytokine which suppresses the production of pro-inflammatory cytokines such as TNFa, IL-6 and IL-12. In this thesis, a requirement for an …
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Differential regulation of cytokine secretion in multiple sclerosis
… reported alterations in immune variables such as cytokine concentrations, immune-related molecules such as MHC and adhesion molecules and chemokines; which may contribute to an imbalance between Thi and Th2 T cellmediated immune response. The aims of the present study were to characterize the …
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Systems analysis of cytokine mediated communication and signaling
… in part through secretion of or response to cytokines. Here, we couple experimental approaches with computational analysis to identify how cytokine communication impacts immune-rich cellular environments. The first part of this work focuses on on understanding intracellular signaling in …
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UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
… secretion of antiviral factors called cytokines. Previous work has identified antiviral cytokines in the placenta that restrict congenital viral infections without inducing excessive inflammation or immune pathology, such as Type III interferons (IFNλ). However, our understanding of how …
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Ethanol Impairs Mechanisms of Macrophage Phagocytosis and Cytokine Production
<p>Extensive evidence indicates that alcohol (ethanol) consumption affects human health by altering normal physiological functions of the immune system. This study investigated the effect of a single <italic>in vivo</italic> exposure of macrophages to clinically relevant levels of ethanol (1.2 and …
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Integrin-ligand interactions and cytokine production by monocytic cells
… receptors is important in the regulation of cytokine production by monocytic cells. Most monocytic cells will express a combination of the different CD23-binding integrins simultaneously and, therefore, the cytokine output of that cell will be the net result of the interaction of CD23 with a …
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