Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 59 for “"Cytochrome P-450"”.
-
Enzymatic activation of cytochrome P-450(cam)
Cytochrome P-450$\sb{\rm cam}$, a camphor monoxygenase from Pseudomonas putida, has served as a model system for the entire family of the P-450s in exploring structure-function relationships, molecular recognition, substrate specificity, and oxygen activation. There are several universal features …
-
Interactions of Isocyanides and Cytochrome P-450(cam)
Made available in DSpace on 2014-12-09T17:36:51Z (GMT). No. of bitstreams: 1 7021078.pdf: 2721091 bytes, checksum: 82c8486d12382d3744b39b43dee1c1ac (MD5) Previous issue date: 1970
-
Spectral and Catalytic Properties of Cytochrome P-450(camphor)
Made available in DSpace on 2014-12-09T17:36:35Z (GMT). No. of bitstreams: 1 7013323.pdf: 3077326 bytes, checksum: 1c623951ef2bfdd11667aea960d89acb (MD5) Previous issue date: 1969
-
Electron spin-lattice relaxation of cytochrome P-450 from Pseudomonas putida
… been taken on o camphor-free low-spin ferric cytochrome P-450 (mo) and the high-spin species of camphor-bound cytochrome P-450 (mos). Relaxation rates were measured at x-and Ku-band frequencies using the technique of pulse-saturation recovery. The data for the low-spin species revealed an …
-
Isolation and Partial Purification of Hepatic Cytochrome P-450 From Untreated Mice
Embargo set by: Seth Robbins for item 78798 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
-
Molecular specificity of substrate recognition and activation in cytochrome P-450(CAM)
… and activation of hydrocarbon substrates by cytochrome P-450$\sb{\rm cam}$. The dependence of the reaction efficiency and specificity on the structural complementarity in the P-450$\sb{\rm cam}$-substrate complex suggests that the active site structure is of paramount importance in mediating …
-
Cyanate Formation Following 2-Chloroacrylonitrile Exposure and the Role of Cytochrome P-450
… of 5-phenyl-1-pentyne (5P1P) an inhibitor of cytochrome P-450. Group 4 received 100 mg/kg of 5P1P one hour before 40 mg/kg of 2-CAN. Three hours following administration, the animals were euthanized via cardiac puncture. Cardiac blood was collected for cyanide and cyanate analysis. Liver and …
-
The Active Site Structure and the Substrate Specificity of Cytochrome P-450(cam)
Cytochrome P-450$\sb{\rm cam}$, from Pseudomonas putida, catalyzes the regio- and stereospecific hydroxylation of the monoterpene d-camphor to afford 5-exo-hydroxycamphor as the sole product. The roles of specific active site structural features in dictating this substrate specificity have been …
-
The interaction of three local anaesthetic agents with hepatic microsomal cytochrome P-450
The effect of inducing agents of cytochrome P-450 on the binding and metabolism of three local anaesthetic agents: lidocaine, mepivacaine and bupivacaine has been investigated. All three local anaesthetic agents bound to the type I binding site of cytochrome P-450, which is characteristic of …
-
Role of Cytochrome P-450 in Methemoglobin Formation by Primaquine with Hamster Liver Microsomes
<p>The role of cytochrome P-450 in <em>in vitro</em> methemoglobin formation by primaquine was investigated through a series of experiments with golden-Syrian hamsters, treated before sacrificing with phenobarbital or 20-methylcholanthrene to increase the cytochrome P-450 content or with cobaltous …
-
Development of New N-Cyclopropyl Based Electron Transfer Probes for Cytochrome P-450 and Monoamine Oxidase Catalyzed Reactions
… the mechanism of monoamine oxidase (MAO) and cytochrome P-450 (cP-450). A photochemical model study of benzophenone triplet (3BP) with the MAO-B substrate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and two of its derivatives, 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine and …
-
Xenobiotic monooxygenase activity and the response to inducers of cytochrome P-450 during embryonic and larval development in fish
… (BPM) activity, and NADPH- and NADH-cytochrome c reductase activities, were followed in microsomes prepared from whole embryos of the estuarine killifish Fundulus heteroclitus. BPM activity was detectable as early as 4 days from fertilization, prior to the appearance of the liver …
-
Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… derivatives were tested against microsomal cytochrome P-450 enzymes (CYP450). Based on a high-throughput fluorescence assay of CYP inhibition, many of the tested compounds inhibited two classes of CYPs: CYP3A4 and CYP19.
-
The Possible Role of Extra-Gonadal Metabolism of Steroids in The Regulation of Plasma Steroid Levels (Cytochrome P-450, Liver)
The circulating level of steroid hormones is determined by both the rate of production by the steroidogenic tissue and by the rate of elimination from the circulation. The rate of metabolism of steroid hormones to more water soluble compounds can be influenced by a variety of factors including diet …
-
Examination of 2,4-D tolerance in perennial Glycine species and the involvement of cytochrome P-450 as a tolerance mechanism
High levels of tolerance to 2,4-D ((2,4-dichlorophenoxy)acetic acid) were expressed at the cell and whole plant level by several accessions of wild perennial Glycine species. Heterotrophic cell suspension cultures of soybean (Glycine max (L.) Merr.) and four perennial Glycine accessions were used …
-
Amino acids responsible for the novel progesterone C-21 hydroxylase activity in a chimera of cytochrome P-450 2C2/2C1
Restriction data tranferred 2014-07-01T11:19:53-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
-
Characterization of Dna Complementary to Rabbit Cytochrome P-450 Messenger-Rnas and Studies on Their Differential Regulation by Phenobarbital (Gene, Expression)
… to understand the regulated biosynthesis of cytochrome P-450 I have prepared a clone bank of mRNA extracts from the liver of a rabbit treated with phenobarbital. Plasmid cDNAs were selected as potential P-450 clones by plus-minus hybridization, in vitro translation of hybrid-selected mRNA, …
-
The effect of dietary zinc on induction of cytochrome p-450 by phenobarbital or 3-methylcholanthrene in male Sprague-Dawley rats
… 40mg/kg had no effect on level of induction of cytochromes P-450 or b₅ by phenobarbital or 3-methylcholanthrene. Hepatic microsomes isolated from rats that received 40mg Zn⁺² were as effective in the biotransformation of aniline, aminopyrine, or p-nitroanisole as hepatic microsomes isolated from …
-
Genetic Variants in the Putidaredoxin-Cytochrome P-450(cam) Electron Transfer Complex: Identification of the Residue Responsible for Redox-State Dependent Complex Stabilization
… three component system comprised of an oxidase, cytochrome P-450$\sb{\rm cam},$ and a two-protein electron transfer chain, putidaredoxin and putidaredoxin reductase (Tyson et al., (1972) J Biol. Chem. 274, 5777-5784). The enzymatic removal of putidaredoxin's C-terminal tryptophan is known to …
Page 1 of 3