Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"Cytidine"”.
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ENDOR and ESR studies of irradiated cytidine
Electronic Thesis or Dissertation
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ESR and ENDOR studies of irradiated guanine and cytidine
Electronic Thesis or Dissertation
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Transcriptional Regulation of the Bacillus Subtilis pyrG Gene Encoding Cytidine Triphosphate Synthetase
I propose that a trans-acting regulatory protein binds to the pyrG GGGC and GCUCCC sequences when intracellular CTP levels are low, which prevents the formation of the terminator and permits transcription readthrough. When intracellular CTP levels are high, I propose the regulatory protein …
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
<p>Activation-induced cytidine deaminase (AID) is indispensable for somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. SHM alters the affinity of an antibody for its corresponding antigen by introducing point mutations within the variable region of the immunoglobulin (Ig) …
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Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation
<p>Activation-induced cytidine deaminase (AID) is essential for two processes of immunoglobulin diversification in germinal center B cells: somatic hypermutation (SHM), in which mutations are introduced into immunoglobulin (Ig) genes, and class-switch recombination (CSR), in which genomic constant …
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Investigation of the role of the DNA-modifying enzyme, activation-induced cytidine deaminase (AID), in cancer
The DNA-editing enzyme, Activation-Induced cytidine Deaminase (AID) is essential for antibody diversification and plays an important role in immunity. AID is specifically expressed in activated B-cells and mutates targeted DNA sites, diversifying the antibody repertoire. Due to its mutagenic …
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
<p>Activation-induced cytidine deaminase (AID) is a mutagenic enzyme that is expressed in mammalian B-cells and initiates the antibody diversification processes of somatic hypermuntation (SHM) and isotype class switch recombination (CSR). AID is targeted to the immunoglobulin gene locus where it …
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An investigation of the impact of the B cell lymphoma factor Activation Induced Cytidine Deaminase (AICDA/AID) on epigenetic plasticity
… of the DNA modifying enzyme Activation-induced cytidine deaminase (AICDA) is a factor linked to cancer progression, particularly B-cell derived non-Hodgkin lymphomas, but has also been associated with other inflammation-associated cancers, including colorectal cancer (CRC). The widely recognised …
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Identification and Characterization of APOBEC1 mRNA Editing Targets: A Transcriptomics Approach
… B mRNA Editing Catalytic polypeptide 1 (APOBEC1) cytidine deaminase is an mRNA editing enzyme that modifies a specific cytidine in the apolipoprotein B (apoB) transcripts of small intestine enterocytes. APOBEC1-mediated cytidine to uridine editing generates an inframe stop codon and results in …
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Biochemical and Structural Studies of RNA and DNA Editing Enzymes
… occurring by way of hydrolytic deamination of cytidine (C) and adenosine (A), is a modification event that profoundly effects on an organisms vitality and quality of life. This study focuses on two types of enzymes---ADAT (adenosine deaminase acting on tRNA) and APOBEC3G (apolipoprotein B …
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Investigation of Ribosome Structure and Ribosome-Transfer Rna Interaction Using T4 Rna Ligase
… catalyzed addition of radioactively labeled cytidine 3',5'-bisphosphate has been used to probe the availability of the 3' ends of rRNAs in the ribosome under varying conditions.
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Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
… through the localizaton of [3H]cytidine that has been incorporated into the membrane-bound intermediate, cytidine diphosphate diacylglycerol. In each age group (postnatal days 4-30), carbachol resulted in more overall labeling than ACPD. For both agonists, the response peaked on …
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A Study of the Pyrimidine Biosynthesis Pathway and its Regulation in Two Distinct Organisms: Methanococcus jannaschii and Pseudomonas aeruginosa
… mutants. By incorporating a functional uridine (cytidine) kinase gene from E. coli it has been possible to isolate a pyrG mutant. In this novel mutant we have been able to independently manipulate the nucleotide pools and study its effects on the enzymes in the biosynthetic pathway. The enzyme …
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Catalysis, Synthesis, and Materials in Support of Chemical Understanding and Global Health
… of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating groups and proceed in overall yield of 75%, a significant advancement over the reported yield of 17%. The step count is reduced from five …
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Design, Synthesis and Study of Novel Nucleobase Analogs
… chemistry developed in the Hudson groupfor cytidine analogs to adenine analogs. However, unlike the cytidine scaffold, the 7-deazaadenine substrate did not cyclize under the Sonogashira cross-coupling/heteroannulation reaction conditions to give the tricyclic adenine and the straight …
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Single-Stranded Dna Scanning And Deamination With Single-Molecule Resolution
… <p>APOBEC3G (Apo3G) and Activation-Induced cytidine Deaminase (AID) are the most notable members of APOBEC enzymes, a family of cytidine (C) deaminases with crucial functions in the immune system. In T cells, Apo3G deaminates C in viral cDNA to halt the replication of HIV 1 strains lacking …
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