Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 93 for “"Cystine"”.
-
Electroanalysis of Cystine and Selenocystine.
Selenium was J.J. Berzelius. discovered in 1817 by the Swedish chemist It was identified in a red deposit that had collected on the floor of a room in which sulfur, obtained as an industrial waste product from a copper mine, had been used; its similarity to tellurium had caused it to have been …
-
The Effects of Various Therapeutics on Cystine Stone Formation
… by the defect of a renal transporter involved in cystine reabsorption. When this transporter is deficient, cystine cannot be broken down and reabsorbed by the body and is excreted via urine in high concentrations. The high levels of cystine present in the urine eventually lead to recurrent cystine …
-
Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
… a cellular antiporter that links the import of L-cystine with the export of L-glutamate. In the central nervous system (CNS), this export contributes to the ambient glutamate levels found in the synaptic cleft. To wit, a 50% reduction in extracellular glutamate has been demonstrated in animals …
-
Investigating Potential Therapies to Decrease the Rate of Cystine Stone Growth in Slc3a1-/- Mice
… transporter involved in the reabsorption of cystine and other dibasic amino acids. This leads to an accumulation of cystine in the urine, resulting in cystine stones. The SLC3A1/SLC7A9 cystine transporter accounts for 90% of cystine reabsorption and mutations in this transporter result in the …
-
Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
… resistance is developing at an alarming rate. Cystine-loop ligand-gated ion channels are important receptors in nematode neurobiology, and as such are promising drug targets. The UNC-49 (GABA-gated chloride channel) and ACC (acetylcholine-gated chloride channel) family of receptors have been …
-
Phenotype-dependent regulation of the system x<sub>C</sub>- cystine/glutamate exchanger by glutathione levels in rat astrocyte primary cultures
… to mediate the exchange of extracellular cystine (L-Cys<sub>2</sub>) for intracellular glutamate (L-Glu). The internalized L-Cys<sub>2</sub> serves as a rate-limiting precursor in the biosynthesis of glutathione (GSH), while the externalized L-Glu can access EAA receptors and contribute to …
-
Phenotype-dependent regulation of the system x<sub>C</sub>- cystine/glutamate exchanger by glutathione levels in rat astrocyte primary cultures
… to mediate the exchange of extracellular cystine (L-Cys<sub>2</sub>) for intracellular glutamate (L-Glu). The internalized L-Cys<sub>2</sub> serves as a rate-limiting precursor in the biosynthesis of glutathione (GSH), while the externalized L-Glu can access EAA receptors and contribute to …
-
Dietary Control of Cystinuria in Maned Wolves (Chrysocyon Brachyurus)
… for reabsorption of the sulfur amino acid cystine. Consequently, excess cystine accumulates in the urine. In acidic conditions, cystine may precipitate into uroliths, potentially obstructing the urethra and ultimately causing bladder rupture or kidney damage. Treatments include medical …
-
New tools for the discovery of pigment gene function
… MFSD12 is required to maintain normal levels of cystine, the oxidized dimer of cysteine, in melanosomes, and to produce cysteinyldopas, the precursors of pheomelanin synthesis made in melanosomes via cysteine oxidation. Tracing and biochemical analyses show that MFSD12 is necessary for the import …
-
Role of Betaine-Homocysteine S-Methyltransferase in Homocysteine Methylation
… either an adequate (4.5g/kg methionine, 3.7g/kg cystine); cystine-devoid (4.5g/kg methionine, 0g/kg cystine) or a methionine-deficient diet (1.5g/kg methionine, 3.7g/kg cystine) alone or in combination with L-CBHcy for 3, 7 or 14 days. L-CBHcy treatment reduced liver glutathione in rats fed the …
-
Novel ferrocenyl benzoyl peptide esters as anti-cancer agents and ferrocenoyl self assembled monolayers as anion sensors
… A series of N-(ferrocenyl)2 and N-(ferrocenoyl)2 cystine dimethyl esters have also been synthesized, characterized and immobilized onto gold electrodes. The electroactivity of the ferrocene and the hydrogen bonding ability of the peptide amide bonds will be exploited in the sensing of anions in …
-
Modulation of thiols and pulmonary immune responses due to diesel exhaust particle (DEP) exposure
… at both 24 and 72 hours. DEP acutely enhanced cystine uptake and reduction in both AM and LNC. In contrast, the intracellular level of GSH in DEP-exposed LNC was significantly reduced despite the increased CYSH level and GSH-ReductaseRTM activity when these cells were cultured with cystine. The …
-
Extracellular amino acid effects on milk protein synthesis and free amino acid pools in cultured rat and bovine mammary cells
… cell. A small linear increase in intracellular cystine was observed with elevated cystine in the medium. The responses in cystine, tryptophan and methionine intracellular pools to extracellular amino acids suggest the concentration of these amino acids in the medium are insufficient to meet the …
-
Nachweis von Salmonella spp. bei Landschildkröten
… resulted from RAPPAPORT-VASSILIADIS and selenite cystine enrichment broth at an incubation temperature of 35-37 °C. The higher critical temperature for incubation of RAPPAPORT-VASSILIADIS enrichment medium is 42 °C; especially Salmonella subspecies IIIb often are inhibited in this medium at this …
-
Prognostic Significance of Xct Polymorphisms and Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy
<p>The plasma membrane x<sub>c</sub><sup>-</sup> cystine/glutamate transporter mediates cellular uptake of cystine in exchange for intracellular glutamate and is highly expressed by pancreatic cancer cells. The <em>xCT</em> gene, encoding the cystine-specific xCT protein subunit of …
-
Chemical modification of the surface of wool
… disuiphide compounds, particularly those of the cystine residues in wool, are investigated. The observed differences between the reactions of both acids are highlighted. Some of the products of the reaction of H3P02 and wool cystine are identified. These include the gases hydrogen suiphide H2S ) …
Page 1 of 5