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Showing 1 to 20 of 260 for “"Cystic Fibrosis"”.
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Cystic Fibrosis-Related Diabetes, Periodontitis, and Quality of Life in Adults with Cystic Fibrosis
… studies on the oral health of individuals with cystic fibrosis (CF), even though poor oral health is a potential contributor to worsening chronic health conditions. Periodontitis, the inflammation of hard tissues that support and anchor the teeth, is a source of infection that could compromise …
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Immune Dysfunction in Cystic Fibrosis
Cystic Fibrosis (CF) is one of the most widespread life-shortening genetic diseases. CF is often diagnosed at birth; there is no cure, and many CF patients die from chronic lung disease at a young age. Patients with CF experience declining pulmonary function related to chronic airway infection, …
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A cystic fibrosis infection monitor
… in people with the inherited disorder, cystic fibrosis (CF). These chronic infections result in a high rate of morbidity and mortality. Once established, the infections are almost impossible to eradicate. Pulmonary exacerbations, thought to be caused by P. aeruginosa, result in further …
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Tomosynthesis in pulmonary cystic fibrosis
… chest tomosynthesis might be used in pulmonary cystic fibrosis, to design and validate a tomosynthesis scoring system, and to determine the effective dose from chest tomosynthesis in children. In a prospective study starting in 2008 clinical chest radiography or computed tomography (CT) were …
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Cystic fibrosis and the gut microbiota
… be altered in numerous disease states, including Cystic Fibrosis (CF) cohorts. This thesis investigates the gut microbiota and microbiome in CF persons and how it may be manipulated through interventions with the potential to improve respiratory symptoms in CF persons. Firstly, in order to survey …
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Biochemical and immunological investigations into cystic fibrosis
… individuals heterozygous and homozygous for the cystic fibrosis (CF) gene, two general approaches were adopted. In the first, attempts were made to produce an antiserum specific for the cystic fibrosis factor (CFF), a substance known to be present in the serum and secreted by fibroblasts of both …
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Tackling Mycobacterium abscessus infection in Cystic Fibrosis
… increasing worldwide, especially among Cystic Fibrosis (CF) patients. During my PhD, I studied key aspects of the biology of M. abscessus spp.; particularly, I studied host-pathogen interactions, antimicrobial resistance mechanisms, and genetic determinants of virulence. First, I …
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Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapies in Cystic Fibrosis: A Retrospective Evaluation of a Nationwide Specialty Pharmacy Database
<p>Background: Cystic fibrosis (CF) is a progressive, genetic disorder caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Patients with CF experience excessive mucus build up and infections leading to complications in the pancreas, lungs, and other organs. …
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Quality of life in adults with cystic fibrosis
… of physical and psychosocial factors observed in cystic fibrosis (CF), has the potential to severely impact on the health related quality of life (HRQoL) experienced by adults with CF. To date, FIRQoL has not been systematically assessed in adults with the disease. This is primarily for two …
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Hispanic Mothers’ Narratives: Experiences of Parenting a Child with Cystic Fibrosis, Health Beliefs, and Health Care Experiences Related to Cystic Fibrosis
… the United States and is also a minority in the cystic fibrosis (CF) community. Therefore, an increase in CF in the U.S. might be anticipated. This study explored stories of Hispanic mothers’ perspectives of parenting their child with CF, health beliefs, and health care experiences. The study …
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Dental Utilization for Medicaid-‐Enrolled Children with Cystic Fibrosis
Background: Despite a highly cariogenic diet and frequent use of inhaled xerostomia-inducing medications, children with CF are believed to be at a lower risk for dental caries (tooth decay) compared to other children. A potential protective factor is increased use of preventive dental care, but not …
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Correction of Cystic Fibrosis-Specific Induced Pluripotent Stem Cells
<p>Cystic Fibrosis (CF), affecting 1 in 3,500 live births in the US, is a disease caused by aberrant expression of the Cystic Fibrosis Transmemebrane Conductance Regulator (CFTR). While a multi-organ disease, CF-related complications and degradation of the lung is the leading cause of mortality. …
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Evolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung
… cause of terminal endobronchial infections in cystic fibrosis patients. This opportunistic pathogen’s extraordinary adaptability arises in part from a large and malleable genome that is rich in regulatory elements. The adaptive potential of Pseudomonas may also be increased by the activity of …
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Evolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung
… cause of terminal endobronchial infections in cystic fibrosis patients. This opportunistic pathogen’s extraordinary adaptability arises in part from a large and malleable genome that is rich in regulatory elements. The adaptive potential of Pseudomonas may also be increased by the activity of …
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
Cystic Fibrosis (CF) is an inherited disease where the dysfunction of a single protein (the Cystic Fibrosis Transmembrane Regulator or CFTR), a chloride transporter found in both epithelial and immune cells, results in persistent infections and inflammation in the airways. It has been shown that …
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
Cystic Fibrosis (CF) is an inherited disease where the dysfunction of a single protein (the Cystic Fibrosis Transmembrane Regulator or CFTR), a chloride transporter found in both epithelial and immune cells, results in persistent infections and inflammation in the airways. It has been shown that …
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Sequence-Specific Gene Correction of Cystic Fibrosis Airway Basal Cells
<p>Cystic fibrosis (CF) is a lethal monogenic disease resulting from mutations in the <em>CFTR </em>gene which encodes a protein involved in regulating anion trans-epithelial transport. A three-base deletion in <em>CFTR </em>(termed as ΔF508 mutation), wherein CFTR protein is misfolded leading to …
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The Cystic Fibrosis Transmembrane Conductance Regulator: Regulation by HSP-90
<p>The hypothesis of this project is that a functionally relevant association exists between CFTR and Hsp90. In testing this hypothesis, (a) the association of CFTR and Hsp90 is confirmed via crosslinking and immunoprecipitation of CFTR from stably transfected HEK-293 cells, electrophoretic …
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