Global ETD Search
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Showing 1 to 3 of 3 for “"Cysteinyl leukotriene receptors"”.
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… the risk for developing colon cancer. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4 are inflammatory mediators that can bind to four known receptors, two of which are the CysLT1R and CysLT2R. Inhibitors of the CysLT1R are currently used in the clinic as asthma medication. LTD4 …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. They are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R is associated with poor prognosis and CysLT2R with good prognosis for …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
Backgound and OBJECTIVE: Leukotriene E4 contributes to airway inflammation by interacting with P2Y12 receptor as well as type 1 and 2 cysteinyl leukotriene receptors. We investigated the effects of P113, a P2Y12 receptor antagonist, on airway inflammation in a mouse model of allergic asthma. …