Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cysteine Peptidase"”.
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… proteinases as well as lysosomal, aspartic and cysteine peptidases. <br>To investigate the role of the lysosomal cysteine peptidase cathepsin B (CTSB) in tumour progression and metastasis, transgenic mice FVB/N-TgN(MMTVPyVT)634Mul, developing multifocal metastasising mammary carcinomas, were …
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Analysis of cathepsin H-deficient mice and identification of a dense cluster of placenta specific peptidase genes
… H-deficient mice a cluster of placenta-specific cysteine peptidase genes was characterized on mouse chromosome 13. This study allowed further defining the map of placenta-specific cysteine peptidase genes and also allowed the identification, in the same cluster, of pseudogenes and of four genes …
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Studies on cathepsin B of Eimeria tenella and pyroglutamyl peptidase of Leishmania major
A sequence encoding a cathepsin B-like cysteine peptidase of the clan CA, family C1 was identified in the genome database of E. tenella. The sequence corresponded to a single copy gene, and did not carry any introns. The E. tenella enzyme, sharing 42% identity with the Toxoplasma gondii toxopain-1, …
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Fasciola hepatica cystatins: recombinant production, biochemical characterisation and efficacy as vaccines
… express an array of temporally regulated cysteine peptidase inhibitors – cystatins – during this migration. The aim of this thesis was to characterise these cystatins and explore the biochemical and biological functions during infection of the mammalian host. Genome and associated …
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Cathepsin Z: Identifizierung und Charakterisierung einer neuen Cysteinpeptidase der Papainfamilie
… Merkmale einer papainähnlichen Cysteinpeptidase lassen sich für CTSZ nachweisen: Neben den typischen Aminosäureresten Cys/His/Asn der katalytischen Triade sind weitere konservierte Regionen zu finden, ebenso ist die Präproenzym-Struktur vorhanden. Zwei potentielle …
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Intracellular trafficking of Leishmania major peptidases
… system by releasing virulence factors. The cysteine peptidase CPB has been shown to be secreted by the parasite and act as such a virulence factor. CPB is released through the flagellar pocket while being trafficked to the lysosome. Thus, in this project, the intracellular localisations of …
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Untersuchungen zur Struktur und Funktion des Legumain-Gens im Modellsystem Maus
… Modellsystem Maus <br> <br>Die Asparaginyl-Endopeptidase Legumain gehört zu den Cystein-Peptidasen und ist im Lysosomen aktiv. Zur Zeit ist sie der einzige Vertreter in der Peptidasefamilie C13 der Säuger. Ursprünglich wurde Legumain in Pflanzen (Bohnen, Leguminosen) und später in Wirbellosen …