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Showing 1 to 18 of 18 for “"Cysteamine"”.
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Formulation studies on cysteamine for the treatment of nephropathic cystinosis.
… and topical administration of the aminothiol, cysteamine (Cystagon TM), which possesses an offensive taste and smell. The oral form frequently causes emesis and should be administered every six hours to be maximally effective. The topical eye-drop treatment requires hourly application to be …
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Characterisation of cysteamine prodrugs for the treatment of cystinosis and evaluation of liquid fill technology.
… the oral administration of the aminothiol, cysteamine (Cystagon(TM)), but this has an offensive taste and smell, can cause vomiting and its metabolites are excreted from the body via breath (halitosis) and sweat, which can cause poor patient compliance. The main research aim was to …
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The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis.
… of studies have shown the ability of the drug cysteamine (Cystagon®) to lower cystine accumulation within cells resulting in reduced organ and tissue damage. Cysteamine therapy however, is associated with a number of side effects involving the gastrointestinal tract and the central nervous …
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Functional relationship between forebrain cholinergic projections and somatostatin neurons in the rat
… using folic acid, a neuro-excitant, and cysteamine, a somatostatin depleter. Folic acid causes a neuron to fire at a much higher rate than normal (Spector, 1971). Folic acid was injected into either the septum or the substantia innominata, and the long-term effect of the resulting acute …
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Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease.
… achieved using both acid chloride (N-decanoyl cysteamine (Compound 1), N-decanoyl L-cysteine ethyl ester (compound 3)) and peptide coupling based reactions, and full characterisation has been achieved. The nitration stage of synthesis was achieved using tert-butyl nitrite and 'fuming' NO as the …
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Fabrication of Chemically Modified Nanometer-sized Gold Electrodes and Their Application in Electrocatalysis at Pt Nanoparticles.
… with Self-Assembled Monolayers (SAMs) of cysteamine and soaked in Pt colloid solutions overnight. Monitoring the decrements of the characteristic steady-state catalytic current for proton reduction indicated that aggregates of Pt nanoparticles are adsorbed on the cysteamine monolayers and …
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Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis.
… for colon-targeted delivery of cystamine, a cysteamine derivative. Orally-ingested cysteamine formulations, used in the treatment of cystinosis, are observed to cause gastrointestinal mucosa irritation, which leads to nausea, vomiting and ulceration in affected patients. Spheronised pellets …
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Electrochemical Studies of The Interaction Between DNA and a Compound Having Anticancer Properties.
… modification of a bare gold electrode using cysteamine. These electrodes have been characterized using electrochemical techniques and were used to study the interaction between DNA and the compound. Our results showed an increase in the adsorption peak current and a negative shift of …
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[Beta]- aminothiols and the regulation of hepatic oxalate production / Paul Wayne Baker.
… on the use of [beta]-aminothiols (cysteine, cysteamine and penicillamine) to decrease endogenous oxalate production by forming adducts with glyoxylate, the immediate precursor of oxalate. They indicate that cysteine delivery drugs like OTC have the potential to aid in management of calcium …
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Modification of thin film composite (TFC) membrane by incorporation with copper nanoparticles (Cu-NPs) for antibacterial properties
… interactions or by covalent bonding with cysteamine as a linker. The electrostatic method was simply to immerse the newly made TFC membranes to the Cu-NPs suspension. Since the CTAB had formed cationic bilayer outside the Cu-NPs, the Cu-NPs was not only adsorbed on the membranes but also …
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Using Electrochemical Method to Study the Interaction Between DNA and a compound Known to Have Anticancer Property.
… bare gold (Au) electrode was modified with cysteamine and our results showed no change in the limiting steady state current as compared to the bare Au electrode. There was a reduction in the steady state current after the modification of the gold electrode with DNA. Immobilization of the DNA …
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Clinical and Molecular Analyses of Intestinal Goblet Cell Acidomucins and Cysteine Metabolism
… of cysteine to Coenzyme A, which releases cysteamine during turnover. Cysteamine is then oxidized to hypotaurine via cysteamine dioxygenase (ADO). In both pathways, hypotaurine is then oxidized to taurine. We confirm that LS174T cells synthesize taurine via the ADO pathway and possibly the …
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A family of multi-functional phosphorescent bioprobes based on the PtPFPP scaffolding moiety
… as PtmPEG31Glc and PtcPEG31Glc respectively, or cysteamine (CA), named PtCA31Glc. Derivatisation with 2-thioelthyl-β-D-glucopyranoside was also performed to evaluate the effects of alternative SH-Glucose structures on cellular uptake, obtaining the corresponding 2Glc derivatives. The new probes …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
… was performed via Michael addition using cysteamine hydrochloride to introduce an amino group over the vinyl bond. The resulting carboxylic acid functional PEO-b-PDLLA diblock copolymers, and amino functional PDLLAs are potential biocompatible polymers that can be utilized to encapsulate …
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Dynamic Crystallization and Stability Engineering in Hybrid Organic-Inorganic Perovskites: Towards Water-Stable and Thermochromic Materials
… semiconductors using the zwitterionic molecule cysteamine (CYS). By varying pH conditions (acidic, neutral, and basic), we tuned the coordination environment to make Pb-S and Pb-N covalent bonds. Crystals synthesized under basic conditions maintainedtheir structure for over one month in direct …
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Exogenous γ-Glutamyl Cycle Compound Supplementation to In Vitro Maturation Medium and the Effects on Subsequent In Vitro Fertilization and Culture Parameters of Porcine Oocytes and Their Impact on Embryo Viability
… were matured in either 3.3 mM cysteine, 150 μM cysteamine, 3.3 mM cysteine and 150 μM cystemaine; 1.0 mM glycine, 2.5 mM glycine, 5.0 mM glycine; 1.0 mM L-glutamate, 2.5 mM L-glutamate, 5.0 mM L-glutamate; and 3.3 mM L-α-aminobutyrate, 25 μM β-mercaptoethanol, 3.3 mM cysteine and 25 μM …
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Tailored Materials for Surface-Enhanced Raman Spectroscopy
… where this was not the case was a mixture of a cysteamine hydrochloride (CYS) and mercaptobenzoic acid (MBA), which showed a surface composition that initially reflected the feedstock before the composition started to change into a more equal ratio as the reaction proceeded to completion