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Showing 1 to 8 of 8 for “"Cystathionine β-synthase"”.
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Synthesis of Inhibitors of Cystathionine β-Synthase
… of H2S is required to maintain homeostasis. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are the two main PLP-dependent enzymes that contribute to H2S metabolism through generation from L-cysteine. A recent study has discovered a link between CBS-derived H2S and tumor growth …
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Cystathionine β synthase (CBS) is a hydrogen sulfide producing enzyme that catalyzes the first step of the transsulfuration pathway converting homocysteine to cystathionine. CBS and the subsequent production of H2S are selectively upregulated in human colon cancer compared to patient matched normal …
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Investigation of cystathionine β-synthase as a cause of mild hyperhomocysteinaemia in patients with peripheral vascular disease
… the enzymes involved in methionine metabolism. Cystathionine β-synthase (CBS) is the most common genetic cause of homocystinuria, the severe form of the disease. The incidence of CBS deficiency in a group of 12 young patients of varied ethnic origin, who had peripheral vascular disease (PVD) …
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Digestible methionine + cysteine:digestible lysine ratio in diets for broilers submitted to inflammatory challenge
… (GSS), methionine adenosyltransferase (MAT2), cystathionine β-synthase (CBS), relative weights of liver and spleen, and dual-energy x-ray absorptiometry (DEXA) estimated fat mass (%) and lean mass (%). The differences were considered significant at an alpha level of 0.05. A linear regression …
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Study on the roles of O-acetylserine (thiol) lyase and thiol dependent reductase 1 of Leishmania
… pathway, involving the action of the enzymes cystathionine β-synthase and cystathionine γ-lyase, to generate cysteine from the essential amino acid methionine. In contrast, Leishmania parasites can synthesise cysteine in two ways but appear unable to salvage it effectively. They contain the …
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Effect of Hydrogen Sulfide Donors on Sympathetic Neurotransmission and Intraocular Pressure of the Eye
… These included aminooxyacetic acid (AOA), a cystathionine-β-synthase (CBS) inhibitor and glibenclamide, a KATP channel blocker. Although AOA (3mM) and glibenclamide (300 μM) had no effect (p>0.05) on [3H]NE release, they both reversed the inhibitory action of GYY 4137 (10-30 μM), ACS67 (0.1-1 …
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Immunometabolism of methyl donors by dairy cattle during periods of negative nutrient balance and heat stress
… increased with choline, while methionine synthase tended to increase, and cystathionine β-synthase was decreased. These changes were associated with increased liver and plasma Met. Changes in plasma biomarkers indicated an improvement in liver function, likely associated with improvements …
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Inhibition of excitatory neurotransmitter activity by hydrogen sulfide in bovine retina, in vitro
… in ocular tissues. In the present study, the Cystathionine β-synthase (CBS) inhibitor, aminooxyacetic acid (AOA; 3 mM) did not have an effect on basal K+-induced [3H]D-aspartate release. However, it completely reversed the inhibitory effects elicited by L-cysteine (1 µM and 10 µM) and GYY 4137 …