Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Cystamine"”.
-
Electrochemical detection of chemical warfare agents
… Boc-NH-Fc-COOH, (11) which was coupled with cystamine using the EDC/HOBt protocol to synthesize the cystamine conjugate [BocHN-Fc-CO-CSA]₂ (12). This molecule is equipped with an amino group that directly linked to the redox receptor. Compound 12 was fully characterized by spectroscopic …
-
Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis.
… spheronisation for colon-targeted delivery of cystamine, a cysteamine derivative. Orally-ingested cysteamine formulations, used in the treatment of cystinosis, are observed to cause gastrointestinal mucosa irritation, which leads to nausea, vomiting and ulceration in affected patients. …
-
The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis.
… number of pro-drug derivatives of cysteamine and cystamine, the disulfide analogue of cysteamine, have been synthesised and evaluated. Pro-drugs were synthesised using a route established in our laboratories. Briefly, cystamine dihydrochloride was basified and allowed to react with a number of …
-
Stable Polymer Micelle Systems as Anti-cancer Drug Delivery Carriers
… e)-b-poly(N-isopropylacrylamide)-N,N-bis(acryloyl)cystamine micelle-like nanoparticles were developed and characterized. When the N,N-bis(acryloyl)cystamine (BAC) was from 0.2 wt% to 0.75 wt% of the mass of poly(N-isopropylacrylamide), diameters of the nanoparticles at 40ºC were less than 150 nm. …
-
Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons
… with only subtle transcriptional effects (cystamine) fails to rescue D2GFP loss. I hope that this system can be of great utility in the validation of effective therapeutic interventions for HD.
-
Chemical functionalization and modification of Au clusters
… fluorenylmethyloxycarbonyl (Fmoc)-glycine (Gly)-cystamine (CSA)-protected Au25(SR)18 NCs. The reactivity of surface amine functional groups of the resulting amine-terminated Au NCs was investigated by the Michael addition reaction of the primary amines with methyl acrylate. Based on the UV-Vis …