Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CysLT2R"”.
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R is associated with poor prognosis and CysLT2R with good prognosis for colorectal cancer patients. Signaling through CysLT1R results in increased proliferation, survival and migration of intestinal epithelial cells, whereas …
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… receptors, two of which are the CysLT1R and CysLT2R. Inhibitors of the CysLT1R are currently used in the clinic as asthma medication. LTD4 has been shown to induce cell proliferation, survival and migration in intestinal epithelial cells (Int407) via the CysLT1R. These mechanisms are often …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… migration, and act via the receptors CysLTiR and CysLT2R. Recently, CysLTs have been implicated in Th2 responses in mouse models, although the exact mechanisms are unclear. Preliminary microarray studies on polarised human Thl and Th2 cells suggested a highly selective expression of CYSLTR1 by …
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The role of CysLT1R in animal models of colorectal cancer
… and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. We have shown that LTD4 via its receptor CysLT1 induces expression of proteins …