Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"CysLT1R"”.
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The role of CysLT1R in animal models of colorectal cancer
… acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. We have shown that LTD4 via its receptor CysLT1 induces expression of …
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… to four known receptors, two of which are the CysLT1R and CysLT2R. Inhibitors of the CysLT1R are currently used in the clinic as asthma medication. LTD4 has been shown to induce cell proliferation, survival and migration in intestinal epithelial cells (Int407) via the CysLT1R. These mechanisms …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R is associated with poor prognosis and CysLT2R with good prognosis for colorectal cancer patients. Signaling through CysLT1R results in increased proliferation, survival and migration of intestinal epithelial …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… to further investigating the effect of LTD4/CysLT1R in tumor progression. The aim of my thesis was to investigate the role of β–catenin signaling in colon cancer progression and the effect of LTD4. I found that activation of CysLT1R via LTD4 increased the translocation and accumulation of …
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The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
… of sensitivity against montelukast, a CysLT1R antagonist. In this context we report that sensitivity of tumors against montelukast could depend on the variation in CICs content, activation of prosurvival factors such as BCL-2 and β-catenin signaling. Collectively, our data showed that …