Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Cys-loop receptor"”.
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The identification of novel cys-loop receptor genes in Dirofilaria immitis
… – but anthelmintic resistance is emerging. Cys-loop ligand-gated ion channels are an untapped source for drug targets essential for nematode neurotransmission. This thesis presents the isolation and preliminary pharmacological characterization of three inhibitory D. immitis ion channels: …
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Molecular pharmacology of an insect GABA receptor
Cys-loop receptors are ligand-gated ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila melanogaster and is a major target site for …
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Isolation and partial characterization of three members of the GGR-1 family in the parasitic nematode Haemonchus contortus
… an urgent need for novel anti-parasitic drugs. Cys-loop ligand gated ion channels have been recognized as important invertebrate specific drug targets. However, specific targets must be identified and characterized prior to drug development. This thesis describes the identification and partial …
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An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
… An analysis of the model of the Hco-UNC-49 receptor has identified potentially interacting residues that may be important to its structure and function. One such potential interaction between K181 and E183, which appears to be unique to nematode GABA receptors, was selected for study based …
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The Lipid-Facing M4 Helix of α4β2 nACh and 5-HT3A Receptors
… in the M4 helices of the 5-HT3A and α4β2 nACh receptors. I used a membrane potential-sensitive fluorescent dye, two-electrode voltage clamp and manual patch-clamp for functional characterisation of mutant receptors in HEK293 cells and Xenopus oocytes, and radioligand binding and …