Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cyr61"”.
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Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
… immediate early genes (IEGs) including CYR61, COX2, BTG2, and ZFP36 were overexpressed in active GO and to a lesser degree in chronic GO, but not in chronic lymphedema. CYR61-responsive genes were also upregulated in active GO. In Study V, associations were found between SNPs in CYR61, …
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RUNX2 promueve la angiogénesis y la expresión de genes blanco con función pro-angiogénica en osteosarcoma
… e Inductor angiogénico rico en cisteína 61 (CYR61). La regulación, mediada por Runx2, de genes blanco angiogénicos se estudió mediante la modulación de la expresión de Runx2 en distintas líneas celulares de osteosarcoma, mediante la utilización de vectores adenovirales y siRNA o shRNA y en …
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A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
… the mechanosensitive proteins YAP, CTGF, and Cyr61 may be viable endogenous therapeutic targets, while CTGF and Cyr61 expression could serve as biomarkers of podocyte mechanical integrity and cell health. Additionally, our preliminary high-throughput drug screens have identified promising …
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The role of extracellular matrix remodelling in brown adipose tissue functions: New candidates
… 4) I determined the role of Aplp2 and Cyr61, the two most relevant ECM-associated candidates involved in BAT functions regulation, in brown adipocytes functions in vitro using a siRNA- mediated knock-down model. In Chapter 3, we demonstrated that ECMr is required for brown adipogenesis …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… of the YAP/TAZ downstream genes like CTGF, CYR61 and ANKRD1 were elevated in the SIRT6-deficient HSCs. Biochemical and mutagenic analyses have revealed that SIRT6 deacetylates YAP and TAZ at key lysine residues and reprograms the composition of the TEA domain transcription factor complex to …