Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Cyclosporine A"”.
-
Characterization of the antiviral activity of cyclosporine A against dengue virus
… are available despite 80 years of research. Cyclosporine A (CsA), an immunosuppressive drug, has emerged as a potential broad-spectrum antiviral effective against various RNA and DNA viruses, including DENV. However, its antiviral mechanism is not fully understood, and its effectiveness …
-
The calcineurin inhibitor cyclosporine A activates the renal Na-(K)-Cl cotransporters via local and systemic mechanisms
The two calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus are potent immunosuppressive drugs that have become indispensable in the post-transplantational therapy and in the treatment of autoimmune diseases. Immunosuppression via CNIs is achieved by inhibition of the calcineurin …
-
Catalytic one-carbon homologation of alkenes
… the capacity to generate unexplored homologs of Cyclosporine A, which exhibit altered pharmacological and biological properties.
-
Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation
… treated with IST (antithymocyte globulin plus cyclosporine A plus steroid) and 25 patients (58.1%) were treated with allogeneic BMT. In the IST group, response rate was 77.8%(2 complete remission, 12 partial remission) and there were two treatment failures. As later complications, acute myeloid …
-
Biocapteur électrochimique pour la quantification d’un immunosuppresseur
… à base d’immunosuppresseurs, tels que la cyclosporine A (CsA) et le tacrolimus. Ces traitements indispensables à la prévention du rejet doivent rigoureusement être contrôlés, car une concentration trop faible conduit au rejet du greffon, tandis qu’un excès devient toxique pour la santé. …
-
MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… Inhibiting the secreted CYPA by CYPA-inhibitor Cyclosporine-A (CsA) in CMs from low-XRCC3 T4-2 cells renders the CM incapable of increasing invasiveness, suggesting that CYPA is downstream of XRCC3. Furthermore, intracellular CYPA levels increase in progression from S1 to invasive T4-2 cells, …
-
To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
… with and without the presence of P-gp inhibitors Cyclosporine A and LY335979. The uptake of calcein-AM was higher within the enterocytes of humanized mice colonoids compared to those obtained from germ free mice. These results correlated with immunohistochemistry on tissue explants that showed a …
-
Regulatory mechanisms in transplantation tolerance: the induction of tolerance by adoptive transfer in MHC-inbred miniature swine
… mismatched renal allografts with 12 days of high Cyclosporine A. Transplantation tolerance in this model is induced and maintained by regulatory T cells. In our study, we used this model to attempt to induce tolerance in naïve recipients through adoptive transfer of donor primed or unprimed …
-
Analysis of the Metabolism of Dextran-Methylprednisolone Succinate Using
… treatments, including corticosteroids,cyclosporine A, and tacrolimus as they relate to liver transplantation is presented. The most common and detrimental side effects are presented for each therapy, and a method to reduce these adverse effects is proposed. As a method of drug delivery …
-
Unraveling the Dynamics of Ser126 Phosphorylation in Paxillin: A Focus on Phosphatase Activity
Paxillin is a focal adhesion adaptor protein essential for cell adhesion and migration, regulated by reversible phosphorylation. In endothelial cells, phosphorylation at serine 126 (Ser126) plays a key role in processes like angiogenesis and vascular permeability. This study aimed to identify the …
-
Polysaccharide-Based Nanocarriers for Improved Drug Delivery
… were selected for loading into the nanocarriers. Cyclosporine A (CyA) was encapsulated within the PSA-PCL micelles, while methotrexate (MTX), and dexamethasone (DM) were entrapped within the PSA-TMC nanoparticles. PSA-PCL micelles were loaded with 0.09 ± 0.02 mg CyA per mg of PSA- PCL, while …
-
Regulation of P-glycoprotein at the Blood-Brain Barrier
… of the fluorescent, P-gp-specific substrate, NBD-cyclosporine A (NBD-CSA), in the lumens of isolated rat brain capillaries using confocal microscopy and quantitative image analysis. Exposing capillaries to the hormone endothelin-1 (ET-1) rapidly and reversibly reduced luminal NBD-CSA accumulation. …
-
Non-toxic concentrations of α-synuclein exacerbate Parkinson's disease-like cell death by inducing mitochondrial dysfunction
… not blocked by the mitochondrial pore inhibitor, cyclosporine A. This suggests that α-syn effects were not mediated through the mitochondrial pore usually associated with dysfunction and cyt c release. α-Syn therefore releases cyt c and Ca2+ by a separate mechanism, such as the formation of α-syn …
-
Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… the effect of prednisone, azathioprine, cyclosporine and methotrexate individually and prednisone in combination with each of these steroid-sparing agents on wild-type and C>G DAF protein (western blotting) and mRNA (quantitative real time PCR) levels and promoter activity (luciferase …
-
Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
… to be strongly Ca²⁺-dependent, sensitive to cyclosporine A (a specific inhibitor of granule exocytosis ), and completely abrogated following Sr²⁺-induced de-granulation of the γδ⁺ T cell effectors, indicating that cytoxicity was mediated predominantly by the granule exocytosis/ perforin …
-
TRIM5α is a poxvirus restriction factor: viral evasion strategies and a pathway to antivirals
… and HIV-1 virions and the inhibitor of CypA, cyclosporine A (CsA), has anti-viral activity. Whilst VACV replication and spread were reduced in CypA<sup>-/-</sup> cells, this phenotype was lost when TRIM5 was also knocked out, showing that CypA is proviral in a TRIM5-dependent manner. …
-
Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… nicotinic acid + quercetin for OAT2, GCDCA-S + cyclosporine A for OAT3, atenolol + mitoxantrone for OCT2) were identified to disentangle overlapping transport and establish selectivity towards OAT2, OAT3, and OCT2. These data provided a practical panel of substrates and substrate-inhibitor pairs …
-
The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment
… 50 μ M, V furosemide at 50 μ M and cyclosporine A at 20 μ M) and frequently co-administered drugs at levels representing the average concentrations found in patients (ritonavir at 5 mg/L and rifampicin at 4 mg/L). The concentrations of efavirenz and lopinavir in PBMCs were …
-
Der Einfluss mechanischer Last auf das Potential multipotenter adulter Keimbahnstammzellen zur kardialen Regeneration
Im Rahmen der vorliegenden Arbeit wurden multipotente adulte Keimbahnstammzellen (maGSCs) der Maus in vivo und in vitro im Hinblick auf ihr Differenzierungspotential unter bestimmten Bedingungen untersucht. In vivo wurde gezeigt, dass sich undifferenzierte maGSCs in normalen Mausherzen ansiedeln …