Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Cyclosporine"”.
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… are available despite 80 years of research. Cyclosporine A (CsA), an immunosuppressive drug, has emerged as a potential broad-spectrum antiviral effective against various RNA and DNA viruses, including DENV. However, its antiviral mechanism is not fully understood, and its effectiveness …
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Histological evaluation of ovine mammary tissue xenografted into cyclosporine treated mice
Cyclosporine (CsA), a fungal peptide with remarkable anti-lymphocytic properties, has been shown to be an effective immunosuppressive agent. In three separate experiments, mice receiving CsA at various doses (8 mg/kg/day in the first two experiments and 70-100 mg/kg/day in the third), were …
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A Study of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
<p>Cyclosporine is an effective immunosuppressive drug that has found widespread application in organ transplantation. However, a few studies have implicated cyclosporine as adversely affecting craniofacial growth in the pediatric population. The purpose of this study was to evaluate the possible …
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A Continued Investigation of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
<p>Cyclosporine is an effective immunosuppressive drug that has found widespread application in organ transplantation. A couple of studies, however, have implicated cyclosporine as adversely affecting craniofacial growth in the pediatric population. The purpose of this follow-up study was to …
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A Continued Investigation of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
<p>Since the mid 1980’s, Cyclosporine has proved to be an effective immunosuppressive drug and now has a widespread application in organ transplantation. Several studies, however, have implicated cyclosporine as adversely affecting craniofacial growth in the pediatric population. <sup>16,18 …
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Pharmacokinetics and Effects on Blood Chemistry of Cyclosporine in Human Infants and Kid Goats
… transplantation. Immunosuppression has been by cyclosporine in both species. However, the pharmacokinetics of cyclosporine (CSA) in both the kid goat and human infant were unknown. Therefore, the pharmacokinetics of CSA were investigated. A single dose study and a long term chronic …
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The calcineurin inhibitor cyclosporine A activates the renal Na-(K)-Cl cotransporters via local and systemic mechanisms
The two calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus are potent immunosuppressive drugs that have become indispensable in the post-transplantational therapy and in the treatment of autoimmune diseases. Immunosuppression via CNIs is achieved by inhibition of the calcineurin …
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Pharmacological interventions against myocardial ischemia and reperfusion injury
… two different pharmacological interventions, cyclosporine A (CsA) and the novel enkephalin analogue EP 94, could reduce myocardial infarct size in different porcine models of myocardial ischaemia and reperfusion. Furthermore, to examine the distribution of the opioid receptor subtypes in the …
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A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?
… if hepatotrophic factors and immunosuppression (Cyclosporine) could modify the restoration of the liver mass after partial hepatectomy in rats.
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Catalytic one-carbon homologation of alkenes
… the capacity to generate unexplored homologs of Cyclosporine A, which exhibit altered pharmacological and biological properties.
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… the effect of prednisone, azathioprine, cyclosporine and methotrexate individually and prednisone in combination with each of these steroid-sparing agents on wild-type and C>G DAF protein (western blotting) and mRNA (quantitative real time PCR) levels and promoter activity (luciferase …
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Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation
… treated with IST (antithymocyte globulin plus cyclosporine A plus steroid) and 25 patients (58.1%) were treated with allogeneic BMT. In the IST group, response rate was 77.8%(2 complete remission, 12 partial remission) and there were two treatment failures. As later complications, acute myeloid …
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Biocapteur électrochimique pour la quantification d’un immunosuppresseur
… à base d’immunosuppresseurs, tels que la cyclosporine A (CsA) et le tacrolimus. Ces traitements indispensables à la prévention du rejet doivent rigoureusement être contrôlés, car une concentration trop faible conduit au rejet du greffon, tandis qu’un excès devient toxique pour la santé. …
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MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… Inhibiting the secreted CYPA by CYPA-inhibitor Cyclosporine-A (CsA) in CMs from low-XRCC3 T4-2 cells renders the CM incapable of increasing invasiveness, suggesting that CYPA is downstream of XRCC3. Furthermore, intracellular CYPA levels increase in progression from S1 to invasive T4-2 cells, …
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To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
… with and without the presence of P-gp inhibitors Cyclosporine A and LY335979. The uptake of calcein-AM was higher within the enterocytes of humanized mice colonoids compared to those obtained from germ free mice. These results correlated with immunohistochemistry on tissue explants that showed a …
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Mitophagy in Heart Failure: A Selective Autophagic Degradation of Mitochondria
… protein modification. Daily injections with cyclosporine (CsA), an inhibitor of both MPT and calcineurin, blunted load-induced mtDNA loss (-28%±2 with CsA vs -83%±10 with vehicle treatment, p<0.01) (n=3) at 4 days post-sTAC. Furthermore, CsA improved survival at 4 days-post sTAC (40% …
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Regulatory mechanisms in transplantation tolerance: the induction of tolerance by adoptive transfer in MHC-inbred miniature swine
… mismatched renal allografts with 12 days of high Cyclosporine A. Transplantation tolerance in this model is induced and maintained by regulatory T cells. In our study, we used this model to attempt to induce tolerance in naïve recipients through adoptive transfer of donor primed or unprimed …
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Analysis of the Metabolism of Dextran-Methylprednisolone Succinate Using
… treatments, including corticosteroids,cyclosporine A, and tacrolimus as they relate to liver transplantation is presented. The most common and detrimental side effects are presented for each therapy, and a method to reduce these adverse effects is proposed. As a method of drug delivery …
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