Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cyclophilin D"”.
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Die Rolle des Adenin-Nukleotid-Translokators-1 (ANT-1) und des Chaperons Cyclophilin D (CypD) bei der Regulation der mitochondrial vermittelten Apoptose
… Überexpression. Der ANT-1-Interaktionspartner Cyclophilin D (CypD) wurde weiterhin als endogener Inhibitor des PTP-Komplexes charakterisiert, der in Tumoren überexprimiert ist.
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Role and regulation of mitochondrial permeability transition in cell death
… the ER-stressor thapsigargin (THG) which led to cyclophilin-D-dependent mitochondrial release of the profusion GTPase Optic Atrophy 1 (OPA1), which controls CJ integrity, and cytochrome c leading to apoptosis. Interference RNA knockdown of Bax blocked OPA1 and cytochrome c release after THG …
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The characterization of the anterograde and retrograde consequences of traumatic axonal injury in a mouse model of diffuse brain injury
… first assessed the impact of genetic deletion of cyclophilin D (CypD), a regulator of the mitochondrial permeability transition pore (mPTP), upon TAI within the perisomatic domain. Via this approach it was determined that CypD deletion reduced the number of injured axons by ~50%, indicating that …
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Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
… A (CsA) binds to the mitochondrial protein cyclophilin D (CypD) and can thereby inhibit mPT, an effect that is unrelated to its immunosuppressive action, and mPT in brain mitochondria was found to be highly sensitive to CsA inhibition. CsA has demonstrated prominent neuroprotective …
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The Role of Bax and Bak in Necrotic Cell Death
… cell death is inhibited in cells deficient for Cyclophilin D (CypD), a mitochondrial prolyl isomerase that resides in the matrix of the mitochondria. CypD is required for programmed necrosis because it regulates the mitochondrial permeability transition pore (MPTP). The MPTP is thought to span …
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Development of New Synthetic Approaches to Biologically-Active Peptides
… to study the peptidyl-prolyl isomerase cyclophilin D (CypD). First, short substrates were synthesised, including a section of Bcl2 (8 amino acids) and F0F1 ATPase subunit B (9 amino acids), which formed a proof of principle. Significant line broadening was observed in the 19F NMR …
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The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection
… mitochondrial membrane integrity by reducing cyclophilin-D (Cyp-D) expression and thus limiting the opening of mitochondria permeability transition pore (mPTP). This conferred protection against the activation of apoptosis and necrosis. More importantly, these beneficial effects were at least …