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Showing 1 to 20 of 30 for “"Cyclophilin"”.
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Identification of Cyclophilin gene family in soybean and characterization of GmCYP1
I identified members of the Cyclophilin (CYP) gene family in soybean (Glycine max) and characterized the GmCYP1, one of the members of soybean CYP. CYPs belong to the immunophilin superfamily with peptidyl-prolyl cis-trans isomerase (PPIase) activity. PPIase catalyzes the interconversion of the …
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MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… spectrometric analysis reveals that secreted cyclophilin A (CYPA) is upregulated in the CM by XRCC3-siRNAs. The addition of recombinant CYPA to naïve T4-2 cells enhances their invasiveness, suggesting that CYPA is sufficient to induce neighboring cell invasiveness. Inhibiting the secreted CYPA …
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Proteomic Analyses of HIV-1 Infected T-cells and the Functional Characterization of Cyclophilin B During HIV-1 Infection
… biological relevance in a cell culture model. Cyclophilin B (CypB) is a member of the peptidyl prolyl isomerase family that is an intracellular chaperon for prolactin and IRF3. It predominantly localizes to the ER, but also contains a nuclear localization signal and can be secreted from cells. …
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Die Rolle des Adenin-Nukleotid-Translokators-1 (ANT-1) und des Chaperons Cyclophilin D (CypD) bei der Regulation der mitochondrial vermittelten Apoptose
… Überexpression. Der ANT-1-Interaktionspartner Cyclophilin D (CypD) wurde weiterhin als endogener Inhibitor des PTP-Komplexes charakterisiert, der in Tumoren überexprimiert ist.
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Endotelinių mikrodalelių tyrimas pirminėje ląstelių kultūroje /
… shed from endothelial cells effected by cyclophilin A in vitro. Healthy subjects were divided into two groups according to cholesterol concentration. Results have shown that in lower cholesterol concentration group, high sistolic blood pressure positively correlated with EMV CD105+. …
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NcCyP41, a two domain neurospora crassa cyclophilin : characterization of its peptidyl-prolyl cis/trans isomerase activity ; isolation and functional analysis of two novel NcCyP41-binding proteins
NcCyP41 and its interactions were characterized. Its domains were cloned in different expression vectors and recombinant proteins purified from E. coli. Interaction of NcCyP41 and its domains with cellular proteins were then analysed by biochemical methods. <br> <br>PPIase activity of the entire …
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ELUCIDATING THE MOLECULAR DETERMINANTS OF P53-MEDIATED PLEIOTROPIC EFFECTS IN SMALL CELL LUNG CANCER
… that culminates in necrosis. We pinpointed the cyclophilin family of peptidyl prolyl cis-trans isomerases as critical determinants of a p53-induced transcriptional program that is specific to SCLC tumors and cell lines that are poised to undergo p53-mediated necrosis. Importantly, inhibition of …
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
<p>Cyclophilin A are a class of peptidyl-prolyl isomerases that catalyzes isomerization of the proline residue within a protein. Cyclophilin A plays an instrumental role in the pathogenesis of HIV and HCV virus. Using structure-based drug we designed and synthesized small molecule inhibitors of …
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Molecular investigations of gene families encoding foldase enzymes in wheat
… of the protein disulfide isomerase (PDI) and cyclophilin families. Little is known about the genes encoding these enzymes in wheat, this information being limited to expression data showing the up-regulation of these genes in the developing endosperm, cDNA clones previously isolated in our lab …
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Role and regulation of mitochondrial permeability transition in cell death
… the ER-stressor thapsigargin (THG) which led to cyclophilin-D-dependent mitochondrial release of the profusion GTPase Optic Atrophy 1 (OPA1), which controls CJ integrity, and cytochrome c leading to apoptosis. Interference RNA knockdown of Bax blocked OPA1 and cytochrome c release after THG …
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Analisi Molecolare del Melanoma
… regulatory subunit A ¿ isoform, protein DJ-1, cyclophilin A and cofilin-1. We show, for the first time, that only specific isoforms of these molecules are overexpressed in melanoma. Different protein profiles were also found between each individual melanoma cell line and the melanocytes. …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… DENV-2 is independent of its target proteins, cyclophilin A or B, which are not required host factors for DENV-2 in Huh7 and A549 cells. In Huh7 and A549 cells, CsA induces interferon regulatory factor-1 (IRF1)-dependent antiviral gene expression. While CsA does not increase IRF1 levels in Huh7 …
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The Proteomic Response of the Carcinus maenas Y-organ Over the Course of the Molt Cycle
… mechanism through which ROS-induced release of cyclophilin A may contribute to YO atrophy during postmolt through the remodeling of structural proteins such as collagen. We support the standing observation of YO atrophy during postmolt by drawing attention to hemolymph protein abundances, …
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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… lipocalin) and cytoplasmic (cyclophilin A) proteins under hypoxia. Furthermore, a plasma signature of increased protease (NE and proteinase 3) activity was identified in COPD versus healthy control plasma. In conclusion, hypoxia engenders a destructive neutrophil phenotype, …
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The characterization of the anterograde and retrograde consequences of traumatic axonal injury in a mouse model of diffuse brain injury
… first assessed the impact of genetic deletion of cyclophilin D (CypD), a regulator of the mitochondrial permeability transition pore (mPTP), upon TAI within the perisomatic domain. Via this approach it was determined that CypD deletion reduced the number of injured axons by ~50%, indicating that …
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Engineering fluorescent imaging platforms to characterise molecular interactions with HIV-1 capsid
… confirmed that binding of the host cell protein cyclophilin A (CypA) to the tubular lattice is substoichiometric due to steric hindrance between CypA molecules. Binding analysis of cleavage and polyadenylation specificity factor subunit 6 (CPSF6) expressed as a full-length protein in a cell-free …
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Progress Towards Integrated Models of HCV Dynamics
… a surprising role for the host cellular protein cyclophilin A in regulating virus assembly as well as clarifying aspects of NS5A phosphorylation. These findings suggest a complex system of regulation linking polyprotein translation, RNA replication, and virion assembly which will require further …
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Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
… A (CsA) binds to the mitochondrial protein cyclophilin D (CypD) and can thereby inhibit mPT, an effect that is unrelated to its immunosuppressive action, and mPT in brain mitochondria was found to be highly sensitive to CsA inhibition. CsA has demonstrated prominent neuroprotective …
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Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
… ESC cultures, and that one of these factors is Cyclophilin A. Finally, we demonstrate that changes in the low molecular weight composition of the medium are likely responsible for the decrease in growth at high plating densities (>104 cells/cm2). We use a numerical model to show that competition …
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