Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Cyclooxygenase-2 (COX-2)"”.
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RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells
… on a possible link between RNAi and the enzyme cyclooxygenase-2 (COX-2) in the field of colorectal cancer (CRC), since it has been established that the transition adenoma-adenocarcinoma and the progression of CRC depend on aberrant constitutive expression of COX-2 gene. In fact, overexpressed …
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The Association of Celecoxib, Rofecoxib, and Non-selective NSAIDs with Indices of Thrombosis and Endothelial Function in the Multi-Ethnic Study of Atherosclerosis
Cyclooxygenase-2 (COX-2) inhibitors and non-selective nonsteroidal anti-inflammatory medications (NSAIDs) have been associated with increased cardiovascular risk. It is the intent of this discussion to explore mechanisms by which celecoxib, rofecoxib, and nonselective anti-inflammatory medications …
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The Impact of Impaired Cyclooxygenase-2 Activity on Mouse Brain Development: A Focus on Sex Differences
… including exposure to antipyretic drugs. Using cyclooxygenase-2 (COX-2) knockin and COX-2 knockout mice, genetic models which mimic exposure to antipyretic drugs, impaired COX-2 activity was found to induce sex-dependent changes in the expression of various neuroimmune markers in the brain …
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Effect of blueberry polyphenols on osteoclast
… of activated T-cells, cytoplasmic 1 (NFATc1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were determined. Blueberry polyphenols were shown to be effective by decreasing iNOS, COX-2 and TRAP levels. This study indicates that blueberry polyphenols decrease osteoclast …
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Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury
… phospholipase A2 (PLA2), an enzyme upstream to cyclooxygenase-2 (COX-2) in the inflammatory cascade. We have found that preconditioning Crotalus venom increases endogenous fibrinogen, decreases perioperative hemorrhage, attenuates COX-2 activity, and reduces postoperative brain edema. Further …
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IDENTIFYING THE GENETIC MECHANISMS IN SEIZURE THRESHOLD REGULATION
… have genetic influences. Expression of neuronal cyclooxygenase-2 (COX-2) gene, PTGS2, a primary gene that regulates prostaglandin synthesis in the normal brain, is enhanced by excitatory neurotransmission and is under tight regulation of N-Methyl-D-Aspartate type glutamate receptor (NMDAR) …
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Involvement of eicosanoid signalling in epithelial cell migration
… D4 (LTD4) or indirectly through inducing cyclooxygenase-2 (COX-2; an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. We observed that direct stimulation with LT D4, induced intestinal epithelial cell migration, through …
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Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… cells. And also, we observed Cd induces cyclooxygenase-2 (COX-2) expression, and thereby prostaglandin E2 (PGE₂) production in bEnd.3. Based on the previous report that PGE₂ is one of the key regulators in the expression of cell adhesion molecule, in this study, we explored the possible …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… the need for effective companion therapies. Cyclooxygenase-2 (COX-2) inhibition has been shown to promote tumor cell differentiation and improve standard therapy response in pancreatic cancer. Here, I evaluate the efficacy of COX-2 inhibition and VEGF blockade in preclinical models of …
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The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
… nucleus beta-catenin induced the expression of cyclooxygenase-2 (COX-2) and the secretion of prostaglandin E2 (PGE2) from the EC. Finally, we have presented data to suggest a novel inflammatory role for apo(a) in which it induces the activation of nuclear factor-kappaB through promotion of the …
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Prostaglandin-Mediated Reinstatement of Drug Taking After Alcohol Drinking by Female Adolescent Rats
… Meth increase the prostaglandin synthesis enzyme cyclooxygenase-2 (COX-2) in the brain but the effect of serial exposure to alcohol and Meth on COX-2 has not been determined. The first study uses a novel method of serial voluntary alcohol drinking and Meth self-administration in female adolescent …
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Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment
… upregulated genes induced by IFN-γ was cyclooxygenase-2 (COX-2). COX-2 catalyzes the first rate-limiting step in the conversion of arachidonic acid to prostaglandins, including PGE2 which leads to inflammation. It is well documented that COX-2 plays an important role in tumor development …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… Strong evidence supports an important role of cyclooxygenase-2 (COX-2) and COX-2 generated prostaglandin E2 (PGE2) during pancreatic fibrosis. Pancreatic stellate cells (PSC) are the predominant source of extracellular matrix production (ECM), thus being the key players in both diseases. Given …
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AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
… re-oxygenation. However, expressions of cyclooxygenase-2 (COX-2) and angiopoietin-2 (Ang-2) were elevated during hypoxia as well as re-oxygenation. Significantly increased capillary density at the end of the 3rd week of hypoxia regressed back toward normoxic baseline during …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… in LV structural and functional parameters. Cyclooxygenase-2 (COX-2) inhibition with Nimesulide significantly attenuated the structural and functional changes associated with LV remodeling due to pressure overload. Prevention treatment with Nimesulide shothat the beneficial effects seen with …
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Identification and Analysis of Omentum Derived Suppressor Cells in Regards to Th17 Inhibition
… of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to generation of nitric oxide (NO) and prostaglandin E2 (PGE2). These mediators inhibited differentiated Th17 cells in vitro, resulting in cell loss, and blockade of cytokine production.</p> <p>Omentum also caused …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… targets for simultaneous therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… targets for simultaneous therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… drugs (NSAIDs). NSAIDs inhibit enzymes in the cyclooxygenase-2 (COX-2) pathway which play a key role in synthesising prostaglandin E2 (PGE2) from arachidonic acid. PGE2 has been implicated in preclinical stages of Alzheimer’s disease, where elevated levels of PGE2 in the cerebrospinal fluid can …
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From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies
… factor nuclear factor kappa B (NF-KB) and enzyme cyclooxygenase 2 (COX- 2) were aberrantly active in VS. NF-KB inhibition, achieved through siRNA, an experimental agent BAYl 1-7082 or a clinically relevant drug curcumin, was cytotoxic against primary VS cells and HEI-193 VS cell line. COX-2 …
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