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Showing 1 to 20 of 75 for “"Cyclooxygenase-2"”.
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Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
COX-2 promotes carcinogenesis, tumor proliferation and growth, angiogenesis, prevention of apoptosis, immunosuppression. Selective inhibition of COX-2 activity in several animal models is associated with decrease in new vessel production in tumors, decreases in new vessel formation, and increases …
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Cyclooxygenase-2 and prostaglandins in human endometrial function
A role for cyclooxygenase enzymes and prostaglandins (such as prostaglandin E2) has been observed in benign endometrial pathologies (endometriosis, excessive blood loss and dysmenorrhoea) and in adenocarcinoma. Cyclooxygenase and prostaglandin E synthase enzymes catalyse the conversion of …
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Durch den Keratin 6-Promotor gesteuerte Expression von Cyclooxygenase-2 in transgenen Mauslinien: Cyclooxygenase-2 bedingte Veränderungen in der Epidermis und anderen stratifizierten Epithelien
… zwischen der Prostaglandin H-Synthase Cyclooxygenase (COX)-2 und Tumorentwicklung. Mit dem Ziel, die Rolle der COX-2 in der epidermalen Tumorentwicklung zu untersuchen, wurden in dieser Arbeit transgene Mäuse etabliert, in denen eine konstitutive Expression der COX-2-cDNA unter der …
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Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… the Pharmacological and Genetic Inhibition of Cyclooxygenase-2 William T. E. Briggs The cyclooxygenase (COX)-2 inhibitors, or “coxibs,” are excellent anti-inflammatory agents, but their reputation has been tarnished by the adverse cardiovascular (CV) events, including heart failure (HF), with …
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Untersuchung der Expression von Cyclooxygenase-2, VEGF und der Gefäßdichte im Nierenzellkarzinom
Die Cyclooxygenase-2 (COX-2) hat Einfluß auf die maligne Transformation von Zellen, deren Proliferation, Migration und Invasion ins Gewebe, auf die Apoptose und auf die Gefäßneubildung in Tumoren. Letztere ist bei der Tumorentstehung ein fundamentaler Prozeß, und VEGF nimmt unter den daran …
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RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells
… on a possible link between RNAi and the enzyme cyclooxygenase-2 (COX-2) in the field of colorectal cancer (CRC), since it has been established that the transition adenoma-adenocarcinoma and the progression of CRC depend on aberrant constitutive expression of COX-2 gene. In fact, overexpressed …
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Chemical probes for studying cyclooxygenase-2 and nitric oxide in living systems
… validation of a fluorescent probe for detecting cyclooxygenase-2 activity with live cells, as well as the discovery of oxygen-dependent regulation that is not observed on the protein expression level. Chapter 3 summarizes our progress towards the development of photoacoustic probes for imaging …
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Cyclooxygenase-2 in cervical neoplasia and the relationship with specific human papillomavirus types
Includes bibliographical references.
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Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… cells. And also, we observed Cd induces cyclooxygenase-2 (COX-2) expression, and thereby prostaglandin E2 (PGE₂) production in bEnd.3. Based on the previous report that PGE₂ is one of the key regulators in the expression of cell adhesion molecule, in this study, we explored the possible …
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Das endogene Cannabinoid Anandamid erhöht Cyclooxygenase-2-abhängig den pulmonalarteriellen Druck in der isolierten Kaninchenlunge
… vollständig inhibierbar. Auch der unspezifische Cyclooxygenasehemmer Aspisol® und der spezifische Cyclooxygenase-2 Hemmer Nimesulide konnten den Druckanstieg durch Anandamid verhindern. Das physiologische Vorkommen der Enzyme FAAH und COX-2 in der Kaninchenlunge wurde mittels RT-PCR nachgewiesen. …
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The Impact of Impaired Cyclooxygenase-2 Activity on Mouse Brain Development: A Focus on Sex Differences
… including exposure to antipyretic drugs. Using cyclooxygenase-2 (COX-2) knockin and COX-2 knockout mice, genetic models which mimic exposure to antipyretic drugs, impaired COX-2 activity was found to induce sex-dependent changes in the expression of various neuroimmune markers in the brain …
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Effekte der Stimmungsstabilisatoren Lithium, Valproat und Lamotrigin auf die Cyclooxygenase-2-Synthese in SK-N-SH Neuroblastomzellen
… und Valproat (VPA) im Rattenhirn sowohl die Cyclooxygenase (COX)-2-Synthese als auch die Prostaglandin E2 (PGE2)-Ausschüttung reduzieren. Aufbauend auf dieser Beobachtung sollten in dieser Arbeit die Effekte der Stimmungsstabilisatoren Lithium, Lamotrigin und Valproat auf die …
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Correlation of Cyclooxygenase-2 and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract
PURPOSE: Cyclooxygenase (COX)-2 plays an important role in cancer progression by affecting tumor cell proliferation, resistance to apoptosis, angiogenesis, and tumor invasion in several types of cancers. However, studies about COX-2 expression in transitional cell carcinoma of the upper urinary …
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Gonadotropin-Releasing Hormone Agonist Treatments Normalize Aromatase and Reduce Cyclooxygenase-2 in Ovarian Endometrioma and Eutopic Endometrium with Endometrosis
… could normalize aromatase cytochrome P450 and cyclooxygenase-2 metabolism by direct action in the eutopic endometrium of endometriosis and ovarian endometrioma. METHODS: Endometrial specimens and ovarian endometrioma tissues were obtained from infertility women undergoing laparoscopic surgery. …
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The Effect of impaired Cyclooxygenase 2 activity on gene regulation in the developing mouse brain and the role of PGE2 in oxidative stress production in Differentiated Neuronal Cells
… from the lipid membrane through the enzyme cyclooxygenase2 (COX-2). These studies aim to investigate how changes in COX-PGE2 signalling can influence mouse gene expression and alter oxidative stress in neuronal cells. In study 1 we use microarray analysis to identify differentially expressed …
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Expression and functional role of cyclooxygenase enzymes in cervical carcinoma
… that epithelial tumors may be regulated by cyclooxygenase enzyme products. The purpose of this thesis was to determine the expression, localisation and possible functional role of cyclooxygenase enzymes in cervical carcinomas. The initial aim of the study was to determine whether …
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The Association of Celecoxib, Rofecoxib, and Non-selective NSAIDs with Indices of Thrombosis and Endothelial Function in the Multi-Ethnic Study of Atherosclerosis
Cyclooxygenase-2 (COX-2) inhibitors and non-selective nonsteroidal anti-inflammatory medications (NSAIDs) have been associated with increased cardiovascular risk. It is the intent of this discussion to explore mechanisms by which celecoxib, rofecoxib, and nonselective anti-inflammatory medications …
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