Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Cyclooxygenase (COX-2)"”.
-
Durch den Keratin 6-Promotor gesteuerte Expression von Cyclooxygenase-2 in transgenen Mauslinien: Cyclooxygenase-2 bedingte Veränderungen in der Epidermis und anderen stratifizierten Epithelien
… zwischen der Prostaglandin H-Synthase Cyclooxygenase (COX)-2 und Tumorentwicklung. Mit dem Ziel, die Rolle der COX-2 in der epidermalen Tumorentwicklung zu untersuchen, wurden in dieser Arbeit transgene Mäuse etabliert, in denen eine konstitutive Expression der COX-2-cDNA unter der …
-
Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie
… bereits gezeigt werden, dass der selektive Cyclooxygenase (COX)-2 Hemmer Celecoxib den Akt-Signalweg beeinflussen kann. Wir untersuchten den Effekt von Celecoxib auf den Akt-Signalweg in Kardiomyozyten und die hypertrophe Antwort. In isolierten Kardiomyozyten hemmte Celecoxib …
-
Effekte der Stimmungsstabilisatoren Lithium, Valproat und Lamotrigin auf die Cyclooxygenase-2-Synthese in SK-N-SH Neuroblastomzellen
… und Valproat (VPA) im Rattenhirn sowohl die Cyclooxygenase (COX)-2-Synthese als auch die Prostaglandin E2 (PGE2)-Ausschüttung reduzieren. Aufbauend auf dieser Beobachtung sollten in dieser Arbeit die Effekte der Stimmungsstabilisatoren Lithium, Lamotrigin und Valproat auf die …
-
Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
… by a positive feedback theory involving cyclooxygenase (COX)-2. Conclusions: Even though PGE2 was shown not to be sufficient to promote Het1a proliferation, regulation of Cyclin D1 and IL-6 transcription via p38 was observed. Furthermore, the expression profile might support the …
-
Correlation of Cyclooxygenase-2 and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract
PURPOSE: Cyclooxygenase (COX)-2 plays an important role in cancer progression by affecting tumor cell proliferation, resistance to apoptosis, angiogenesis, and tumor invasion in several types of cancers. However, studies about COX-2 expression in transitional cell carcinoma of the upper urinary …
-
Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… the Pharmacological and Genetic Inhibition of Cyclooxygenase-2 William T. E. Briggs The cyclooxygenase (COX)-2 inhibitors, or “coxibs,” are excellent anti-inflammatory agents, but their reputation has been tarnished by the adverse cardiovascular (CV) events, including heart failure (HF), with …
-
Environmental risk assessment and human pharmaceuticals: limitations and future improvements
… The molecular docking results indicate that the cyclooxygenase (COX 2) primary drug target homologues are probably functional in O.mykiss, S.salar and D.rerio but not D.pulex. It appears from this data that bioinformatics and molecular docking indeed may be a useful tool to aid ecotoxicology …
-
Intracellular signalling by arachidonic acid metabolites
… PGE2, but not cytokine (IL-6/IL-8) production or cyclooxygenase (COX)-2 expression. This effect was attenuated by GW9662, by transfection with dominant negative PPAR constructs, and was reproduced by rosiglitazone. At micromolar (1-10 µM) concentrations, 15d-PGJ2 inhibited IL-1β-stimulated COX-2, …
-
Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… cells. And also, we observed Cd induces cyclooxygenase-2 (COX-2) expression, and thereby prostaglandin E2 (PGE₂) production in bEnd.3. Based on the previous report that PGE₂ is one of the key regulators in the expression of cell adhesion molecule, in this study, we explored the possible …