Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 146 for “"Cyclooxygenase"”.
-
Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
COX-2 promotes carcinogenesis, tumor proliferation and growth, angiogenesis, prevention of apoptosis, immunosuppression. Selective inhibition of COX-2 activity in several animal models is associated with decrease in new vessel production in tumors, decreases in new vessel formation, and increases …
-
Cyclooxygenase-2 and prostaglandins in human endometrial function
A role for cyclooxygenase enzymes and prostaglandins (such as prostaglandin E2) has been observed in benign endometrial pathologies (endometriosis, excessive blood loss and dysmenorrhoea) and in adenocarcinoma. Cyclooxygenase and prostaglandin E synthase enzymes catalyse the conversion of …
-
Role of Cyclooxygenase Isoforms in Peripheral Neuropathic Pain Model
In human, the neuropathic pain evoked by nerve injury includes severe mechanical allodynia and hyperalgesia in the region where the nerve innervates. The mechanism of the development of neuropathic pain was not yet well known and the solution for it was not also elucidated. The ligation of L5 …
-
Durch den Keratin 6-Promotor gesteuerte Expression von Cyclooxygenase-2 in transgenen Mauslinien: Cyclooxygenase-2 bedingte Veränderungen in der Epidermis und anderen stratifizierten Epithelien
… zwischen der Prostaglandin H-Synthase Cyclooxygenase (COX)-2 und Tumorentwicklung. Mit dem Ziel, die Rolle der COX-2 in der epidermalen Tumorentwicklung zu untersuchen, wurden in dieser Arbeit transgene Mäuse etabliert, in denen eine konstitutive Expression der COX-2-cDNA unter der …
-
Expression and functional role of cyclooxygenase enzymes in cervical carcinoma
… that epithelial tumors may be regulated by cyclooxygenase enzyme products. The purpose of this thesis was to determine the expression, localisation and possible functional role of cyclooxygenase enzymes in cervical carcinomas. The initial aim of the study was to determine whether …
-
Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… the Pharmacological and Genetic Inhibition of Cyclooxygenase-2 William T. E. Briggs The cyclooxygenase (COX)-2 inhibitors, or “coxibs,” are excellent anti-inflammatory agents, but their reputation has been tarnished by the adverse cardiovascular (CV) events, including heart failure (HF), with …
-
Untersuchung der Expression von Cyclooxygenase-2, VEGF und der Gefäßdichte im Nierenzellkarzinom
Die Cyclooxygenase-2 (COX-2) hat Einfluß auf die maligne Transformation von Zellen, deren Proliferation, Migration und Invasion ins Gewebe, auf die Apoptose und auf die Gefäßneubildung in Tumoren. Letztere ist bei der Tumorentstehung ein fundamentaler Prozeß, und VEGF nimmt unter den daran …
-
RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells
… on a possible link between RNAi and the enzyme cyclooxygenase-2 (COX-2) in the field of colorectal cancer (CRC), since it has been established that the transition adenoma-adenocarcinoma and the progression of CRC depend on aberrant constitutive expression of COX-2 gene. In fact, overexpressed …
-
Diverse roles of cyclooxygenase in the central nervous system and the periphery
Cyclooxygenase (COX) is a rate limiting enzyme for prostaglandin (PG) synthesis. As inflammatory mediator, COX-2 and its product PGs modulate cytokines, chemokines and adhesion molecules in periphery and central nervous system. In the brain, COX-2 is increased by neurodegenerative disease and …
-
Chemical probes for studying cyclooxygenase-2 and nitric oxide in living systems
… validation of a fluorescent probe for detecting cyclooxygenase-2 activity with live cells, as well as the discovery of oxygen-dependent regulation that is not observed on the protein expression level. Chapter 3 summarizes our progress towards the development of photoacoustic probes for imaging …
-
Influence of the reducing agent triphenylphosphine on cyclooxygenase-1 metabolism of arachidonic acid
<p>Cyclooxygenase (COX) metabolizes the polyunsaturated fatty acid arachidonic acid (AA) to PGG2, a cyclic endoperoxide that also contains a hydroperoxide, which is subsequently reduced to an alcohol in the enzyme to yield PGH2. Reactions catalyzed by COX-1 are significantly influenced by lipid …
-
Cyclooxygenase-2 in cervical neoplasia and the relationship with specific human papillomavirus types
Includes bibliographical references.
-
The Involvement of the Cyclooxygenase Enzymes in the Gallus Domesticus Model of Ovarian Cancer
… of the work presented was to determine if the cyclooxygenase (COX) enzymes are involved in ovarian carcinogenesis in the hen as a model for the human disease. The expression patterns of COX-1 and -2 mRNA and protein in normal hen ovaries and hen ovarian tumors were determined. COX-1 mRNA …
-
Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… cells. And also, we observed Cd induces cyclooxygenase-2 (COX-2) expression, and thereby prostaglandin E2 (PGE₂) production in bEnd.3. Based on the previous report that PGE₂ is one of the key regulators in the expression of cell adhesion molecule, in this study, we explored the possible …
-
The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
… studies have demonstrated over-expression of cyclooxygenase-2 enzyme and enhanced synthesis of prostanoids, such as prostaglandin E2, in cervical carcinomas. Prostaglandin E2 mediates its effects by interacting with one of four receptors termed EPI-4. Expression and signalling of EP receptors, …
-
Das endogene Cannabinoid Anandamid erhöht Cyclooxygenase-2-abhängig den pulmonalarteriellen Druck in der isolierten Kaninchenlunge
… vollständig inhibierbar. Auch der unspezifische Cyclooxygenasehemmer Aspisol® und der spezifische Cyclooxygenase-2 Hemmer Nimesulide konnten den Druckanstieg durch Anandamid verhindern. Das physiologische Vorkommen der Enzyme FAAH und COX-2 in der Kaninchenlunge wurde mittels RT-PCR nachgewiesen. …
-
The Impact of Impaired Cyclooxygenase-2 Activity on Mouse Brain Development: A Focus on Sex Differences
… including exposure to antipyretic drugs. Using cyclooxygenase-2 (COX-2) knockin and COX-2 knockout mice, genetic models which mimic exposure to antipyretic drugs, impaired COX-2 activity was found to induce sex-dependent changes in the expression of various neuroimmune markers in the brain …
Page 1 of 8