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Showing 1 to 20 of 90 for “"Cyclodextrins"”.
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Inclusion of alkylparabens in cyclodextrins
… to prepare crystalline inclusion complexes with cyclodextrins (CDs), as hosts, and drugs, as guests, characterise them using various methods and attempt to elucidate their structures by X-ray diffraction methods to establish the detailed mode of drug inclusion in the solid state. Cyclodextrins …
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Complexation of Organic Guests and Coordination of Metal Ions by Cyclodextrins: Role of Cyclodextrins in Metal-Guest Interactions
… to prevent loss of iron as iron hydroxides. Cyclodextrins (CDs) have demonstrated the ability to increase the efficiency of Fenton degradation of aromatic pollutant species. The increase in degradation efficiency observed in the CD Fenton reaction systems has been credited to the formation of …
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Cyclodextrins : molecular wheels for supramolecular chemistry / Julia Lock.
… variety of supramolecular architectures based on cyclodextrins.
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Aminolysis of the 4-acetoxybenzoate anion catalysed by cyclodextrins
… anion (4-ABA) in the presence of three cyclodextrins (Ì-CD, Ý-CD, and Þ-CD) in basic aqueous solution, the results indicate that 4-ABA binds to Ì-CD fairly weakly while no binding is observed between 4-ABA and Ý-CD or Þ-CD. The effects of the three CDs on the kinetics of the aminolysis …
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Physicochemical study of inclusion of drug molecules in cyclodextrins
Inclusion of drug molecules in cyclodextrins can significantly improve various aspects of their performance and has resulted in the use of cyclodextrins (CDs) for a wide variety of pharmaceutical applications. Consequently, the cyclodextrin inclusion of drugs has received great interest in the …
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Physicochemical studies of the inclusion of selected agrochemicals in cyclodextrins
… four pesticides with native and derivatised cyclodextrins (CDs). The pesticides studied included: the phenylurea herbicide, cycluron; an organochlorine insecticide, endosulfan; an organophosphorus insecticide, fenitrothion; and the chloroacetanilide herbicide, acetochlor. A study of CD …
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Investigations of the solution properties of both unmodified and modified cyclodextrins
… internal motions of the three main, unmodified cyclodextrins (namely a, β and y). The conformational space and dynamics of the interglycosidic dihedral angles, individual glucose tilting and verticallibrations of each glucose unit is investigated. Also the hydrogen bonding across the glycosidic …
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The design of cyclodextrins for delivery of siRNA - a structure-activity relationship
… aims to investigate the potential of modified cyclodextrins (CDs) as alternative biomaterials for siRNA delivery and to identify the optimum functional groups to maximise safety and efficacy. To help reduce the overall cationic charge and the potential for in vivo toxicity a co-formulation …
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Stabilization of transition states of organic reactions by cyclodextrins, micelles, and dendrimers
… aromatic acetals and orthoesters is retarded by cyclodextrins. The magnitude of the effect depends on the size of cyclodextrin cavity. The observed rate retardation is attributed to the unfavourable transition state binding to cyclodextrins, and possible retardation of diffusional separation of …
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Exploration of Using Cyclodextrins as Novel Additives and Fining Agents in Wine
… phenols. The current project aimed to explore cyclodextrins (CDs) as a novel approach to amelioration. CDs are a group of glucose-based oligosaccharides, which are characterised by their truncated cone structure, and hydrophilic outer surface and hydrophobic inner cavity. These properties offer …
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Complexation between cyclodextrins and phenylurea herbicides in solution and in the solid state
… the same phenylureas in solution with selected cyclodextrins. The kneading experiments were carried out first to determine whether the phenylureas would complex in the solid-state. The phenylureas were then subjected to complexation by means of co-precipitation under different conditions of …
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Enzymatic degradation of alpha and beta cyclodextrins by bacteroides from the human colon
… human colon were tested for ability to degrade cyclodextrins (CD). Twenty four strains were able to degrade CD. Cyclodextrinase in two of these strains B. ovatus 3524 and B. distasonis Cl8-7 has been studied. Organisms were grown on a minimal medium containing CD (0.5%), and cyclodextrinase …
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Controlled Release of Natural Antioxidants from Polymer Food Packaging by Molecular Encapsulation with Cyclodextrins
… encapsulation of natural antioxidants using cyclodextrins may be used as a controlled release mechanism within polymer food packaging to gradually deliver an effective antioxidant concentration to a food product, thereby, limiting oxidation, maintaining nutritional quality, and extending …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
<p>Solubility behavior is one of the most challenging aspects for drug commercialization and often the main reason of drug that do not reach to its full potential. Now nearly 60% new chemical entities possess solubility problems, whereas practically no drug products with less than 10 µg/ml …
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Molecular Dynamics Simulations to Enhance Stability in Biopharmaceutical Formulations - A Focus on Cyclodextrins and Interfaces
L'abstract è presente nell'allegato / the abstract is in the attachment
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Studies on the interaction of surfactants and neutral cyclodextrins by capillary electrophoresis. Application to chiral analysis
… composed of SDS in the presence of neutral cyclodextrins were considered. Firstly, the effect of the CDs on the CMC of the surfactant was evaluated by CE experiments. Furthermore, a new CE approach based on electric current measurement was developed for the estimation of the stoichiometry as …
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Design and synthesis of novel β-cyclodextrins and their application as chiral stationary phases for gas chromatography.
… use of systems containing a chiral selector. Cyclodextrins (CDs) and modified cyclodextrins have been used as chiral selectors for their ability to form host-guest complexes with various analytes. The scaffold of the CD allows for assembly of functional groups with controlled geometry. CDs can …
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An investigation into the use of B-cyclodextrins as additives to effect enantiomeric separation by reversed phase HPLC.
The occurrence of chirality in organic molecules and its significance for the clinical effects of drug molecules is reviewed. A need is established for suitable methods, both analytical and preparative for the separation of enantiomers. The present range of analytical methods used for …
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