Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Cyclitol"”.
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The Reactions of Ethyl Ethoxymagnesiomalonate With Some Simple Aliphatic Diacid Chlorides.
… the biochemical and pharmacological interest in cyclitols, alone, and in combination with other molecules, the biosynthesis of these compounds has been studied in a number of laboratories. Kiely and Sherman recently developed a chemical model which describes the proposed mechanism for the …
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Synthetic Studies on Tunicamycin Towards the Discovery of Antimetastatic Agents
… selective DPAGT1 inhibitors based on tunicamycin cyclitol analogs. The complex pseudo-disaccharide and nucleoside segments are assembled in a one-pot Büchner-Curtius-Schlotterbeck reaction in a wet solvent system. A series of DPAGT1 inhibitors can be synthesized in 11-12 chemical steps from the …
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Total synthesis enabled by nickel-catalyzed transformations: Dearomative carboamination and methylenecyclopropane annulation
… of our newly formed diene product to access the cyclitol core. Upon the completion of the synthesis of the 7-deoxypancratistatin and pancratistatin, we then developed a directed cupration/oxidation reaction to create a direct synthetic connection between the two natural products. Chapter 3 …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
<p>Inositol is a six-carbon cyclitol that is ubiquitous in biological systems. It is a precursor for the synthesis of numerous biologically important compounds, including inositol phosphates and phosphoinositides that are essential for cell function and viability. Inositol compounds play a role in …