Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Cyclin-abhängige Kinasen"”.
-
Identifizierung von Cyclin L2 und des Spleißfaktors SF3B1 als Substrate der Proteinkinase DYRK1A
… vitro substrates were identified. Two of them, cyclin L2 and SF3B1, were chosen for further investigations. Cyclin L2 combines a cyclin domain with an arginine-serine-rich (RS)-domain and was extensively characterised in this work. Alternatively spliced transcripts were identified and their …
-
Charakterisierung von Cyclin L2 : ein neuer Vertreter der Cyclin-Familie
… the protein function of DYRK1A remains unclear. Cyclin L2, a recently identified substrates of DYRK1A, combines the unique combination of cyclin domain and arginine-serine-rich domain (rs-domain). These rs-domains comprise a hallmark for splicing factors. The intention of this thesis was to …
-
Die humanen Sir2-Ortholoe SIRT1 und SIRT2 als Substrate Cyclin-abhängiger Kinasen
… SIRT2 was previously found to be a substrate for cyclin dependent kinases (CDKs) in a solid phase phosphorylation screen, the aim of this work was to characterise the phosphorylation of SIRT2 by CDKs and to define the functional relevance of this modification. Moreover, the biological effect of …