Global ETD Search
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Showing 1 to 8 of 8 for “"Cyclin-Dependent Kinase Inhibitor p21"”.
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Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
… evidence suggest that TBX3 may repress the cyclin-dependent kinase inhibitor p21WAF1, which has a role in a myriad of processes including cell cycle arrest, senescence, apoptosis, differentiation and DNA replication and repair. The current study therefore aimed to explore this possibility …
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Functional characterization of the cyclin-dependent kinase inhibitor p21 by gene targeting in the mouse
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Overcoming radioresistance by targeting p21 in cancer
… cellular responses mainly regulated by p53. The cyclin-dependent kinase inhibitor p21 (CDKN1A), also known as p21WAF1/Cip1, is the main p53 transcriptional target and it is traditionally recognized as a tumor suppressor since it is involved in genomic stability preservation, cell cycle arrest or …
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Characterization of Fasting-Induced p21 Expression and Protection of Intestinal Stem Cells
<p>The cyclin dependent kinase inhibitor, p21, plays a key role in cell cycle. Additionally, the p21 gene, <italic>Cdkn1a</italic> (hereafter <italic>p21</italic>) is often used as a marker of cellular stress. To investigate <italic>p21</italic> promoter activity under basal conditions and in …
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The N-terminal Domain of the Y-box Binding Protein YB-1 Plays a Major Role in Cell Proliferation and Apoptosis
… in levels of cell cycle specific genes like the cyclin dependent kinase inhibitor - p21.</p> <p> The current study is based on the hypothesis that the defects seen in the heterozygous mutant DT-40 cells were due to a dominant negative effect of the potential YB-1 N-terminal truncated protein. The …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… genes is <em>CDKN1A</em> which encodes the cyclin dependent kinase inhibitor p21. p21 halts cell-cycle progression in response to DNA damage and can also induce senescence. However, p21 expression in cancer cells undergoing chemotherapy allows survival by entering a senescent state in a …
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Single-Cell Image Analysis Enables High-Throughput Phenotypic Drug Screen and Elucidates Cell-Fate Decision Principles
… population. We monitored the dynamics of p21 to understand the proliferation-senescence cell-fate decision in single cells under non-lethal dose of chemotherapy via time-lapse microscopy before, during and days after treatment. Surprisingly, while high p21 is associated with senescence at …
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Single-Cell Image Analysis Enables High-Throughput Phenotypic Drug Screen and Elucidates Cell-Fate Decision Principles
… population. We monitored the dynamics of p21 to understand the proliferation-senescence cell-fate decision in single cells under non-lethal dose of chemotherapy via time-lapse microscopy before, during and days after treatment. Surprisingly, while high p21 is associated with senescence at …